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Gene Information
Gene symbol: SERPINE2
Gene name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
HGNC ID: 8951
Synonyms: PN1, GDN, PNI, nexin
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | NPHS2 | 1 hits |
| 2 | PLAUR | 1 hits |
| 3 | SERPINE1 | 1 hits |
| 4 | SNX9 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 25587125 | Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis. |
| 2 | 25587125 | Mice showed an increase of glomerular plasminogen activator inhibitor type 1 (PAI-1) mRNA and aberrant endothelial PAI-1 protein already on day 1, before thrombosis and proteinuria. |
| 3 | 25587125 | Immortalized podocytes treated with PAI-1 and the urokinase plasminogen activator (uPA) complex caused significant cell detachment, whereas podocytes treated with PAI-1 or uPA alone or with the PAI-1/uPA complex pretreated with an anti-uPA receptor (uPAR) antibody failed to cause detachment. |
| 4 | 25587125 | The administration of PAI-1 inhibitor or uPAR-blocking antibody protected cultured podocytes from cell detachment. |
| 5 | 25587125 | In conclusion, PAI-1/uPA complex-mediated uPAR-dependent podocyte β1-integrin endocytosis represents a novel mechanism of glomerular injury leading to progressive podocytopenia. |
| 6 | 25587125 | Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis. |
| 7 | 25587125 | Mice showed an increase of glomerular plasminogen activator inhibitor type 1 (PAI-1) mRNA and aberrant endothelial PAI-1 protein already on day 1, before thrombosis and proteinuria. |
| 8 | 25587125 | Immortalized podocytes treated with PAI-1 and the urokinase plasminogen activator (uPA) complex caused significant cell detachment, whereas podocytes treated with PAI-1 or uPA alone or with the PAI-1/uPA complex pretreated with an anti-uPA receptor (uPAR) antibody failed to cause detachment. |
| 9 | 25587125 | The administration of PAI-1 inhibitor or uPAR-blocking antibody protected cultured podocytes from cell detachment. |
| 10 | 25587125 | In conclusion, PAI-1/uPA complex-mediated uPAR-dependent podocyte β1-integrin endocytosis represents a novel mechanism of glomerular injury leading to progressive podocytopenia. |
| 11 | 28266622 | Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte. |
| 12 | 28266622 | Here we identified the protein sorting nexin 9 (SNX9) as a novel facilitator of podocin endocytosis in a yeast two-hybrid analysis. |
| 13 | 28266622 | Our results revealed and confirmed that SNX9 interacts with podocin exclusively through the Bin-Amphiphysin-Rvs (BAR) domain of SNX9. |
| 14 | 28266622 | Finally, an analysis of human glomerular disease biopsy samples demonstrated strong SNX9 expression and co-localization with podocin in samples representative of severe podocyte injury, such as IgA nephropathy with poor prognosis, membranous nephropathy and focal segmental glomerulosclerosis. |
| 15 | 28266622 | In conclusion, we identified SNX9 as a facilitator of podocin endocytosis in severe podocyte injury and demonstrated the expression of SNX9 in the podocytes of both nephropathy model mice and human patients with irreversible glomerular disease. |