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Gene Information
Gene symbol: SH2D5
Gene name:
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABL1 | 1 hits |
| 2 | AGT | 1 hits |
| 3 | INPPL1 | 1 hits |
| 4 | NPHS1 | 1 hits |
| 5 | RAPH1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22194892 | Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin. |
| 2 | 22194892 | Upon activation Nephrin recruits and regulates a protein complex that includes Ship2 (SH2 domain containing 5' inositol phosphatase), Filamin and Lamellipodin, proteins important in regulation of actin and focal adhesion dynamics, as well as lamellipodia formation. |
| 3 | 22194892 | Using the previously described CD16-Nephrin clustering system, Nephrin ligation or activation resulted in phosphorylation of the actin crosslinking protein Filamin in a p21 activated kinase dependent manner. |
| 4 | 22194892 | In the CD16-Nephrin clustering model, Nephrin ligation resulted in abnormal morphology of actin tails in human podocytes when Ship2, Filamin or Lamellipodin were individually knocked down. |
| 5 | 26510503 | Angiotensin II down-regulates nephrin-Akt signaling and induces podocyte injury: roleof c-Abl. |
| 6 | 26510503 | Recent studies have shown that nephrin plays a vital role in angiotensin II (Ang II)-induced podocyte injury and thus contributes to the onset of proteinuria and the progression of renal diseases, but its specific mechanism remains unclear. c-Abl is an SH2/SH3 domain-containing nonreceptor tyrosine kinase that is involved in cell survival and regulation of the cytoskeleton. |
| 7 | 26510503 | Phosphorylated nephrin is able to interact with molecules containing SH2/SH3 domains, suggesting that c-Abl may be a downstream molecule of nephrin signaling. |
| 8 | 26510503 | Here we report that Ang II-infused rats developed proteinuria and podocyte damage accompanied by nephrin dephosphorylation and minimal interaction between nephrin and c-Abl. |
| 9 | 26510503 | In vitro, Ang II induced podocyte injury and nephrin and Akt dephosphorylation, which occurred in tandem with minimal interaction between nephrin and c-Abl. |
| 10 | 26510503 | Moreover, Ang II promoted c-Abl phosphorylation and interaction between c-Abl and SH2 domain-containing 5'-inositol phosphatase 2 (SHIP2). c-Abl small interfering RNA (siRNA) and STI571 (c-Abl inhibitor) provided protection against Ang II-induced podocyte injury, suppressed the Ang II-induced c-Abl-SHIP2 interaction and SHIP2 phosphorylation, and maintained a stable level of nephrin phosphorylation. |
| 11 | 26510503 | These results indicate that c-Abl is a molecular chaperone of nephrin signaling and the SHIP2-Akt pathway and that the released c-Abl contributes to Ang II-induced podocyte injury. |