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Gene Information
Gene symbol: SH3D19
Gene name: SH3 domain containing 19
HGNC ID: 30418
Synonyms: DKFZp434D0215, EVE1, EBP, Kryn, SH3P19
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATF6 | 1 hits |
| 2 | CASP1 | 1 hits |
| 3 | CASP3 | 1 hits |
| 4 | DDIT3 | 1 hits |
| 5 | HSP90B1 | 1 hits |
| 6 | HSPA5 | 1 hits |
| 7 | INS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 29500363 | Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress. |
| 2 | 29500363 | Here we use established activating transcription factor 6 (ATF6)- and ER stress element (ERSE)-luciferase assays alongside a novel high throughput imaging-based C/EBP homologous protein (CHOP) assay to examine three models of improved insulin sensitivity. |
| 3 | 29500363 | We find that by improving insulin sensitivity at the level of the insulin receptor (IR), either by IR over-expression or by knocking down the negative regulator of IR activity, protein tyrosine-phosphatase 1B (PTP1B), podocytes are protected from ER stress caused by fatty acids or diabetic media containing high glucose, high insulin and inflammatory cytokines TNFα and IL-6. |
| 4 | 29500363 | However, contrary to this, knockdown of the negative regulator of PI3K-Akt signalling, phosphatase and tensin homolog deleted from chromosome 10 (PTEN), sensitizes podocytes to ER stress and apoptosis, despite increasing Akt phosphorylation. |
| 5 | 29843457 | TAU limited proteinuria and podocytes foot processes effacement, and balanced slit diaphragm nephrin and glomerular claudin 1 expressions. |
| 6 | 29843457 | Remarkably, TAU downregulated glomerular ER stress markers (GRP78, GRP94), pro-apoptotic C/EBP homologous protein, activated caspase 3, tubular caspase1, and mitochondrial chaperone GRP75, but maintained anti-apoptotic HSP25. |