Ignet

Gene Information

Gene symbol: SLC29A2

Gene name: solute carrier family 29 (nucleoside transporters), member 2

HGNC ID: 11004

Synonyms: DER12

Related Genes

#	Gene Symbol	Number of hits
1	INS	1 hits
2	INSR	1 hits
3	PIK3CA	1 hits
4	SLC29A1	1 hits

Related Sentences

#	PMID	Sentence
1	28842605	Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy.
2	28842605	In ex vivo glomeruli, high D-glucose decreased nucleoside uptake mediated by ENT1 and ENT2 transporters, resulting in augmented extracellular levels of adenosine.
3	28842605	Particularly, insulin through insulin receptor/PI3K pathway markedly upregulated ENT2 uptake activity to restores the extracellular basal level of adenosine.
4	28842605	Using primary cultured rat podocytes as a cellular model, we found insulin was able to increase ENT2 maximal velocity of transport.
5	28842605	Also, PI3K activity was necessary to maintain ENT2 protein levels in the long term.
6	28842605	In glomeruli of streptozotocin-induced diabetic rats, insulin deficiency leads to decreased activity of ENT2 and chronically increased extracellular levels of adenosine.
7	28842605	Treatment of diabetic rats with adenosine deaminase attenuated both the glomerular loss of nephrin and proteinuria.
8	28842605	In conclusion, we evidenced ENT2 as a target of insulin signaling and sensitive to dysregulation in diabetes, leading to chronically increased extracellular adenosine levels and thereby setting conditions conducive to kidney injury.
9	28842605	Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy.
10	28842605	In ex vivo glomeruli, high D-glucose decreased nucleoside uptake mediated by ENT1 and ENT2 transporters, resulting in augmented extracellular levels of adenosine.
11	28842605	Particularly, insulin through insulin receptor/PI3K pathway markedly upregulated ENT2 uptake activity to restores the extracellular basal level of adenosine.
12	28842605	Using primary cultured rat podocytes as a cellular model, we found insulin was able to increase ENT2 maximal velocity of transport.
13	28842605	Also, PI3K activity was necessary to maintain ENT2 protein levels in the long term.
14	28842605	In glomeruli of streptozotocin-induced diabetic rats, insulin deficiency leads to decreased activity of ENT2 and chronically increased extracellular levels of adenosine.
15	28842605	Treatment of diabetic rats with adenosine deaminase attenuated both the glomerular loss of nephrin and proteinuria.
16	28842605	In conclusion, we evidenced ENT2 as a target of insulin signaling and sensitive to dysregulation in diabetes, leading to chronically increased extracellular adenosine levels and thereby setting conditions conducive to kidney injury.
17	28842605	Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy.
18	28842605	In ex vivo glomeruli, high D-glucose decreased nucleoside uptake mediated by ENT1 and ENT2 transporters, resulting in augmented extracellular levels of adenosine.
19	28842605	Particularly, insulin through insulin receptor/PI3K pathway markedly upregulated ENT2 uptake activity to restores the extracellular basal level of adenosine.
20	28842605	Using primary cultured rat podocytes as a cellular model, we found insulin was able to increase ENT2 maximal velocity of transport.
21	28842605	Also, PI3K activity was necessary to maintain ENT2 protein levels in the long term.
22	28842605	In glomeruli of streptozotocin-induced diabetic rats, insulin deficiency leads to decreased activity of ENT2 and chronically increased extracellular levels of adenosine.
23	28842605	Treatment of diabetic rats with adenosine deaminase attenuated both the glomerular loss of nephrin and proteinuria.
24	28842605	In conclusion, we evidenced ENT2 as a target of insulin signaling and sensitive to dysregulation in diabetes, leading to chronically increased extracellular adenosine levels and thereby setting conditions conducive to kidney injury.
25	28842605	Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy.
26	28842605	In ex vivo glomeruli, high D-glucose decreased nucleoside uptake mediated by ENT1 and ENT2 transporters, resulting in augmented extracellular levels of adenosine.
27	28842605	Particularly, insulin through insulin receptor/PI3K pathway markedly upregulated ENT2 uptake activity to restores the extracellular basal level of adenosine.
28	28842605	Using primary cultured rat podocytes as a cellular model, we found insulin was able to increase ENT2 maximal velocity of transport.
29	28842605	Also, PI3K activity was necessary to maintain ENT2 protein levels in the long term.
30	28842605	In glomeruli of streptozotocin-induced diabetic rats, insulin deficiency leads to decreased activity of ENT2 and chronically increased extracellular levels of adenosine.
31	28842605	Treatment of diabetic rats with adenosine deaminase attenuated both the glomerular loss of nephrin and proteinuria.
32	28842605	In conclusion, we evidenced ENT2 as a target of insulin signaling and sensitive to dysregulation in diabetes, leading to chronically increased extracellular adenosine levels and thereby setting conditions conducive to kidney injury.
33	28842605	Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy.
34	28842605	In ex vivo glomeruli, high D-glucose decreased nucleoside uptake mediated by ENT1 and ENT2 transporters, resulting in augmented extracellular levels of adenosine.
35	28842605	Particularly, insulin through insulin receptor/PI3K pathway markedly upregulated ENT2 uptake activity to restores the extracellular basal level of adenosine.
36	28842605	Using primary cultured rat podocytes as a cellular model, we found insulin was able to increase ENT2 maximal velocity of transport.
37	28842605	Also, PI3K activity was necessary to maintain ENT2 protein levels in the long term.
38	28842605	In glomeruli of streptozotocin-induced diabetic rats, insulin deficiency leads to decreased activity of ENT2 and chronically increased extracellular levels of adenosine.
39	28842605	Treatment of diabetic rats with adenosine deaminase attenuated both the glomerular loss of nephrin and proteinuria.
40	28842605	In conclusion, we evidenced ENT2 as a target of insulin signaling and sensitive to dysregulation in diabetes, leading to chronically increased extracellular adenosine levels and thereby setting conditions conducive to kidney injury.
41	28842605	Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy.
42	28842605	In ex vivo glomeruli, high D-glucose decreased nucleoside uptake mediated by ENT1 and ENT2 transporters, resulting in augmented extracellular levels of adenosine.
43	28842605	Particularly, insulin through insulin receptor/PI3K pathway markedly upregulated ENT2 uptake activity to restores the extracellular basal level of adenosine.
44	28842605	Using primary cultured rat podocytes as a cellular model, we found insulin was able to increase ENT2 maximal velocity of transport.
45	28842605	Also, PI3K activity was necessary to maintain ENT2 protein levels in the long term.
46	28842605	In glomeruli of streptozotocin-induced diabetic rats, insulin deficiency leads to decreased activity of ENT2 and chronically increased extracellular levels of adenosine.
47	28842605	Treatment of diabetic rats with adenosine deaminase attenuated both the glomerular loss of nephrin and proteinuria.
48	28842605	In conclusion, we evidenced ENT2 as a target of insulin signaling and sensitive to dysregulation in diabetes, leading to chronically increased extracellular adenosine levels and thereby setting conditions conducive to kidney injury.
49	28842605	Deficient Insulin-mediated Upregulation of the Equilibrative Nucleoside Transporter 2 Contributes to Chronically Increased Adenosine in Diabetic Glomerulopathy.
50	28842605	In ex vivo glomeruli, high D-glucose decreased nucleoside uptake mediated by ENT1 and ENT2 transporters, resulting in augmented extracellular levels of adenosine.
51	28842605	Particularly, insulin through insulin receptor/PI3K pathway markedly upregulated ENT2 uptake activity to restores the extracellular basal level of adenosine.
52	28842605	Using primary cultured rat podocytes as a cellular model, we found insulin was able to increase ENT2 maximal velocity of transport.
53	28842605	Also, PI3K activity was necessary to maintain ENT2 protein levels in the long term.
54	28842605	In glomeruli of streptozotocin-induced diabetic rats, insulin deficiency leads to decreased activity of ENT2 and chronically increased extracellular levels of adenosine.
55	28842605	Treatment of diabetic rats with adenosine deaminase attenuated both the glomerular loss of nephrin and proteinuria.
56	28842605	In conclusion, we evidenced ENT2 as a target of insulin signaling and sensitive to dysregulation in diabetes, leading to chronically increased extracellular adenosine levels and thereby setting conditions conducive to kidney injury.