Ignet

Gene Information

Gene symbol: SLC2A2

Gene name: solute carrier family 2 (facilitated glucose transporter), member 2

HGNC ID: 11006

Related Genes

#	Gene Symbol	Number of hits
1	AGT	1 hits
2	SLC2A1	1 hits
3	SLC2A3	1 hits
4	SLC2A4	1 hits
5	SLC2A8	1 hits

Related Sentences

#	PMID	Sentence
1	15383720	Transporters GLUT2 and GLUT4 were expressed in over 90% podocytes.
2	15383720	Of the GLUT2- and GLUT4-expressing cells, approximately one-fourth expressed the membrane-bound fraction.
3	15383720	We conclude that cultured rat podocytes possess a differentiated glucose transport system consisting chiefly of facilitative GLUT2 and GLUT4 transporters.
4	15383720	Transporters GLUT2 and GLUT4 were expressed in over 90% podocytes.
5	15383720	Of the GLUT2- and GLUT4-expressing cells, approximately one-fourth expressed the membrane-bound fraction.
6	15383720	We conclude that cultured rat podocytes possess a differentiated glucose transport system consisting chiefly of facilitative GLUT2 and GLUT4 transporters.
7	15383720	Transporters GLUT2 and GLUT4 were expressed in over 90% podocytes.
8	15383720	Of the GLUT2- and GLUT4-expressing cells, approximately one-fourth expressed the membrane-bound fraction.
9	15383720	We conclude that cultured rat podocytes possess a differentiated glucose transport system consisting chiefly of facilitative GLUT2 and GLUT4 transporters.
10	29686650	At the cellular level, the mechanisms leading to the development of insulin resistance include mutations in the insulin receptor gene, impairments in the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway, or perturbations in the trafficking of glucose transporters (GLUTs), which mediate the uptake of glucose into cells.
11	29686650	Podocytes express several GLUTs, including GLUT1, GLUT2, GLUT3, GLUT4, and GLUT8.
12	29686650	Of these, the most studied ones are GLUT1 and GLUT4, both shown to be insulin responsive in podocytes.
13	29686650	After insulin stimulation, GLUT4 is sorted into GLUT4-containing vesicles (GCVs) that translocate to the plasma membrane.
14	29686650	Studies have revealed novel molecular regulators of the GLUT trafficking in podocytes and unraveled unexpected roles for GLUT1 and GLUT4 in the development of DKD, summarized in this review.
15	30087656	In this study we investigated the capacity of AngII to modulate glucose uptake in mouse podocytes expressing the human AT1 receptor (AT1R+) after 5 days of exposure to normal (NG, 5.6 mmol/L) or to high (HG, 30 mmol/L) glucose.
16	30087656	In podocytes cultured under NG conditions, AngII inhibited insulin-stimulated glucose uptake.
17	30087656	Regardless of the presence or absence of AngII, no effect of insulin on glucose uptake was observed in HG cells.
18	30087656	Stimulation of glucose transport by AngII was mediated by protein kinase C and by phosphoinositide 3-kinase.
19	30087656	Glucose dependent surface expression of the glucose transporters GLUT1, GLUT2, and GLUT4 was modulated by AngII in a time and glucose concentration dependent manner.
20	30087656	Furthermore, despite its inhibitory effect on insulin's action, AngII elevated the number of podocyte insulin receptors in both NG and HG cultured cells.
21	30087656	These findings demonstrate that AngII modulates podocyte basal, as well as insulin-dependent glucose uptake by regulating glucose transporters and insulin signaling.