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Gene Information
Gene symbol: SLC2A8
Gene name: solute carrier family 2 (facilitated glucose transporter), member 8
HGNC ID: 13812
Synonyms: GLUTX1, GLUT8
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | SLC2A1 | 1 hits |
| 3 | SLC2A2 | 1 hits |
| 4 | SLC2A3 | 1 hits |
| 5 | SLC2A4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15741607 | Additionally, GLUT8 expression was studied using two different models of insulin resistance, GLUT4-/- and db/db mice. |
| 2 | 29686650 | At the cellular level, the mechanisms leading to the development of insulin resistance include mutations in the insulin receptor gene, impairments in the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway, or perturbations in the trafficking of glucose transporters (GLUTs), which mediate the uptake of glucose into cells. |
| 3 | 29686650 | Podocytes express several GLUTs, including GLUT1, GLUT2, GLUT3, GLUT4, and GLUT8. |
| 4 | 29686650 | Of these, the most studied ones are GLUT1 and GLUT4, both shown to be insulin responsive in podocytes. |
| 5 | 29686650 | After insulin stimulation, GLUT4 is sorted into GLUT4-containing vesicles (GCVs) that translocate to the plasma membrane. |
| 6 | 29686650 | Studies have revealed novel molecular regulators of the GLUT trafficking in podocytes and unraveled unexpected roles for GLUT1 and GLUT4 in the development of DKD, summarized in this review. |