Ignet

Gene Information

Gene symbol: SLK

Gene name: STE20-like kinase

HGNC ID: 11088

Synonyms: STK2, se20-9, KIAA0204

Related Genes

#	Gene Symbol	Number of hits
1	HSF1	1 hits
2	HSPA1A	1 hits
3	JUN	1 hits
4	KCNN2	1 hits
5	MAPK14	1 hits
6	NPHS1	1 hits
7	PLK1	1 hits
8	SYNPO	1 hits
9	TAOK1	1 hits

Related Sentences

#	PMID	Sentence
1	12965890	This screening demonstrated expression of a protein kinase consistent with SK2, a group II germinal center kinase and homolog of human Ste20-like kinase (SLK).
2	20889563	Podocyte injury and albuminuria in mice with podocyte-specific overexpression of the Ste20-like kinase, SLK.
3	20889563	In cultured cells, SLK promotes F-actin destabilization as well as apoptosis, partially via the p38 kinase pathway.
4	20889563	To better understand the effects of SLK in vivo, a transgenic mouse model was developed where SLK was expressed in a podocyte-specific manner using the mouse nephrin promoter.
5	20889563	Podocyte injury and albuminuria in mice with podocyte-specific overexpression of the Ste20-like kinase, SLK.
6	20889563	In cultured cells, SLK promotes F-actin destabilization as well as apoptosis, partially via the p38 kinase pathway.
7	20889563	To better understand the effects of SLK in vivo, a transgenic mouse model was developed where SLK was expressed in a podocyte-specific manner using the mouse nephrin promoter.
8	20889563	Podocyte injury and albuminuria in mice with podocyte-specific overexpression of the Ste20-like kinase, SLK.
9	20889563	In cultured cells, SLK promotes F-actin destabilization as well as apoptosis, partially via the p38 kinase pathway.
10	20889563	To better understand the effects of SLK in vivo, a transgenic mouse model was developed where SLK was expressed in a podocyte-specific manner using the mouse nephrin promoter.
11	27216364	Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.
12	27216364	When highly expressed, SLK signals via c-Jun N-terminal kinase and p38 to induce apoptosis, and it exacerbates apoptosis induced by ischemia-reperfusion injury.
13	27216364	We address the interaction of SLK with the heat shock factor 1 (HSF1)-Hsp70 pathway.
14	27216364	Increased expression of SLK in GECs (following transfection) induced HSF1 transcriptional activity.
15	27216364	Moreover, HSF1 transcriptional activity was increased by in vitro ischemia-reperfusion injury (chemical anoxia/recovery) and heat shock, and in both instances was amplified further by SLK overexpression.
16	27216364	HSF1 binds to promoters of target genes, such as Hsp70 and induces their transcription.
17	27216364	By analogy to HSF1, SLK stimulated Hsp70 expression.
18	27216364	Hsp70 was also enhanced by anoxia/recovery and was further amplified by SLK overexpression.
19	27216364	Induction of HSF1 and Hsp70 was dependent on the kinase activity of SLK, and was mediated via polo-like kinase-1.
20	27216364	Transfection of constitutively active HSF1 enhanced Hsp70 expression and inhibited SLK-induced apoptosis.
21	27216364	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-μ.
22	27216364	In conclusion, increased expression/activity of SLK activates the HSF1-Hsp70 pathway.
23	27216364	Hsp70 attenuates the primary proapoptotic effect of SLK.
24	27216364	Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.
25	27216364	When highly expressed, SLK signals via c-Jun N-terminal kinase and p38 to induce apoptosis, and it exacerbates apoptosis induced by ischemia-reperfusion injury.
26	27216364	We address the interaction of SLK with the heat shock factor 1 (HSF1)-Hsp70 pathway.
27	27216364	Increased expression of SLK in GECs (following transfection) induced HSF1 transcriptional activity.
28	27216364	Moreover, HSF1 transcriptional activity was increased by in vitro ischemia-reperfusion injury (chemical anoxia/recovery) and heat shock, and in both instances was amplified further by SLK overexpression.
29	27216364	HSF1 binds to promoters of target genes, such as Hsp70 and induces their transcription.
30	27216364	By analogy to HSF1, SLK stimulated Hsp70 expression.
31	27216364	Hsp70 was also enhanced by anoxia/recovery and was further amplified by SLK overexpression.
32	27216364	Induction of HSF1 and Hsp70 was dependent on the kinase activity of SLK, and was mediated via polo-like kinase-1.
33	27216364	Transfection of constitutively active HSF1 enhanced Hsp70 expression and inhibited SLK-induced apoptosis.
34	27216364	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-μ.
35	27216364	In conclusion, increased expression/activity of SLK activates the HSF1-Hsp70 pathway.
36	27216364	Hsp70 attenuates the primary proapoptotic effect of SLK.
37	27216364	Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.
38	27216364	When highly expressed, SLK signals via c-Jun N-terminal kinase and p38 to induce apoptosis, and it exacerbates apoptosis induced by ischemia-reperfusion injury.
39	27216364	We address the interaction of SLK with the heat shock factor 1 (HSF1)-Hsp70 pathway.
40	27216364	Increased expression of SLK in GECs (following transfection) induced HSF1 transcriptional activity.
41	27216364	Moreover, HSF1 transcriptional activity was increased by in vitro ischemia-reperfusion injury (chemical anoxia/recovery) and heat shock, and in both instances was amplified further by SLK overexpression.
42	27216364	HSF1 binds to promoters of target genes, such as Hsp70 and induces their transcription.
43	27216364	By analogy to HSF1, SLK stimulated Hsp70 expression.
44	27216364	Hsp70 was also enhanced by anoxia/recovery and was further amplified by SLK overexpression.
45	27216364	Induction of HSF1 and Hsp70 was dependent on the kinase activity of SLK, and was mediated via polo-like kinase-1.
46	27216364	Transfection of constitutively active HSF1 enhanced Hsp70 expression and inhibited SLK-induced apoptosis.
47	27216364	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-μ.
48	27216364	In conclusion, increased expression/activity of SLK activates the HSF1-Hsp70 pathway.
49	27216364	Hsp70 attenuates the primary proapoptotic effect of SLK.
50	27216364	Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.
51	27216364	When highly expressed, SLK signals via c-Jun N-terminal kinase and p38 to induce apoptosis, and it exacerbates apoptosis induced by ischemia-reperfusion injury.
52	27216364	We address the interaction of SLK with the heat shock factor 1 (HSF1)-Hsp70 pathway.
53	27216364	Increased expression of SLK in GECs (following transfection) induced HSF1 transcriptional activity.
54	27216364	Moreover, HSF1 transcriptional activity was increased by in vitro ischemia-reperfusion injury (chemical anoxia/recovery) and heat shock, and in both instances was amplified further by SLK overexpression.
55	27216364	HSF1 binds to promoters of target genes, such as Hsp70 and induces their transcription.
56	27216364	By analogy to HSF1, SLK stimulated Hsp70 expression.
57	27216364	Hsp70 was also enhanced by anoxia/recovery and was further amplified by SLK overexpression.
58	27216364	Induction of HSF1 and Hsp70 was dependent on the kinase activity of SLK, and was mediated via polo-like kinase-1.
59	27216364	Transfection of constitutively active HSF1 enhanced Hsp70 expression and inhibited SLK-induced apoptosis.
60	27216364	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-μ.
61	27216364	In conclusion, increased expression/activity of SLK activates the HSF1-Hsp70 pathway.
62	27216364	Hsp70 attenuates the primary proapoptotic effect of SLK.
63	27216364	Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.
64	27216364	When highly expressed, SLK signals via c-Jun N-terminal kinase and p38 to induce apoptosis, and it exacerbates apoptosis induced by ischemia-reperfusion injury.
65	27216364	We address the interaction of SLK with the heat shock factor 1 (HSF1)-Hsp70 pathway.
66	27216364	Increased expression of SLK in GECs (following transfection) induced HSF1 transcriptional activity.
67	27216364	Moreover, HSF1 transcriptional activity was increased by in vitro ischemia-reperfusion injury (chemical anoxia/recovery) and heat shock, and in both instances was amplified further by SLK overexpression.
68	27216364	HSF1 binds to promoters of target genes, such as Hsp70 and induces their transcription.
69	27216364	By analogy to HSF1, SLK stimulated Hsp70 expression.
70	27216364	Hsp70 was also enhanced by anoxia/recovery and was further amplified by SLK overexpression.
71	27216364	Induction of HSF1 and Hsp70 was dependent on the kinase activity of SLK, and was mediated via polo-like kinase-1.
72	27216364	Transfection of constitutively active HSF1 enhanced Hsp70 expression and inhibited SLK-induced apoptosis.
73	27216364	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-μ.
74	27216364	In conclusion, increased expression/activity of SLK activates the HSF1-Hsp70 pathway.
75	27216364	Hsp70 attenuates the primary proapoptotic effect of SLK.
76	27216364	Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.
77	27216364	When highly expressed, SLK signals via c-Jun N-terminal kinase and p38 to induce apoptosis, and it exacerbates apoptosis induced by ischemia-reperfusion injury.
78	27216364	We address the interaction of SLK with the heat shock factor 1 (HSF1)-Hsp70 pathway.
79	27216364	Increased expression of SLK in GECs (following transfection) induced HSF1 transcriptional activity.
80	27216364	Moreover, HSF1 transcriptional activity was increased by in vitro ischemia-reperfusion injury (chemical anoxia/recovery) and heat shock, and in both instances was amplified further by SLK overexpression.
81	27216364	HSF1 binds to promoters of target genes, such as Hsp70 and induces their transcription.
82	27216364	By analogy to HSF1, SLK stimulated Hsp70 expression.
83	27216364	Hsp70 was also enhanced by anoxia/recovery and was further amplified by SLK overexpression.
84	27216364	Induction of HSF1 and Hsp70 was dependent on the kinase activity of SLK, and was mediated via polo-like kinase-1.
85	27216364	Transfection of constitutively active HSF1 enhanced Hsp70 expression and inhibited SLK-induced apoptosis.
86	27216364	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-μ.
87	27216364	In conclusion, increased expression/activity of SLK activates the HSF1-Hsp70 pathway.
88	27216364	Hsp70 attenuates the primary proapoptotic effect of SLK.
89	27216364	Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.
90	27216364	When highly expressed, SLK signals via c-Jun N-terminal kinase and p38 to induce apoptosis, and it exacerbates apoptosis induced by ischemia-reperfusion injury.
91	27216364	We address the interaction of SLK with the heat shock factor 1 (HSF1)-Hsp70 pathway.
92	27216364	Increased expression of SLK in GECs (following transfection) induced HSF1 transcriptional activity.
93	27216364	Moreover, HSF1 transcriptional activity was increased by in vitro ischemia-reperfusion injury (chemical anoxia/recovery) and heat shock, and in both instances was amplified further by SLK overexpression.
94	27216364	HSF1 binds to promoters of target genes, such as Hsp70 and induces their transcription.
95	27216364	By analogy to HSF1, SLK stimulated Hsp70 expression.
96	27216364	Hsp70 was also enhanced by anoxia/recovery and was further amplified by SLK overexpression.
97	27216364	Induction of HSF1 and Hsp70 was dependent on the kinase activity of SLK, and was mediated via polo-like kinase-1.
98	27216364	Transfection of constitutively active HSF1 enhanced Hsp70 expression and inhibited SLK-induced apoptosis.
99	27216364	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-μ.
100	27216364	In conclusion, increased expression/activity of SLK activates the HSF1-Hsp70 pathway.
101	27216364	Hsp70 attenuates the primary proapoptotic effect of SLK.
102	27216364	Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.
103	27216364	When highly expressed, SLK signals via c-Jun N-terminal kinase and p38 to induce apoptosis, and it exacerbates apoptosis induced by ischemia-reperfusion injury.
104	27216364	We address the interaction of SLK with the heat shock factor 1 (HSF1)-Hsp70 pathway.
105	27216364	Increased expression of SLK in GECs (following transfection) induced HSF1 transcriptional activity.
106	27216364	Moreover, HSF1 transcriptional activity was increased by in vitro ischemia-reperfusion injury (chemical anoxia/recovery) and heat shock, and in both instances was amplified further by SLK overexpression.
107	27216364	HSF1 binds to promoters of target genes, such as Hsp70 and induces their transcription.
108	27216364	By analogy to HSF1, SLK stimulated Hsp70 expression.
109	27216364	Hsp70 was also enhanced by anoxia/recovery and was further amplified by SLK overexpression.
110	27216364	Induction of HSF1 and Hsp70 was dependent on the kinase activity of SLK, and was mediated via polo-like kinase-1.
111	27216364	Transfection of constitutively active HSF1 enhanced Hsp70 expression and inhibited SLK-induced apoptosis.
112	27216364	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-μ.
113	27216364	In conclusion, increased expression/activity of SLK activates the HSF1-Hsp70 pathway.
114	27216364	Hsp70 attenuates the primary proapoptotic effect of SLK.
115	27216364	Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.
116	27216364	When highly expressed, SLK signals via c-Jun N-terminal kinase and p38 to induce apoptosis, and it exacerbates apoptosis induced by ischemia-reperfusion injury.
117	27216364	We address the interaction of SLK with the heat shock factor 1 (HSF1)-Hsp70 pathway.
118	27216364	Increased expression of SLK in GECs (following transfection) induced HSF1 transcriptional activity.
119	27216364	Moreover, HSF1 transcriptional activity was increased by in vitro ischemia-reperfusion injury (chemical anoxia/recovery) and heat shock, and in both instances was amplified further by SLK overexpression.
120	27216364	HSF1 binds to promoters of target genes, such as Hsp70 and induces their transcription.
121	27216364	By analogy to HSF1, SLK stimulated Hsp70 expression.
122	27216364	Hsp70 was also enhanced by anoxia/recovery and was further amplified by SLK overexpression.
123	27216364	Induction of HSF1 and Hsp70 was dependent on the kinase activity of SLK, and was mediated via polo-like kinase-1.
124	27216364	Transfection of constitutively active HSF1 enhanced Hsp70 expression and inhibited SLK-induced apoptosis.
125	27216364	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-μ.
126	27216364	In conclusion, increased expression/activity of SLK activates the HSF1-Hsp70 pathway.
127	27216364	Hsp70 attenuates the primary proapoptotic effect of SLK.
128	27216364	Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.
129	27216364	When highly expressed, SLK signals via c-Jun N-terminal kinase and p38 to induce apoptosis, and it exacerbates apoptosis induced by ischemia-reperfusion injury.
130	27216364	We address the interaction of SLK with the heat shock factor 1 (HSF1)-Hsp70 pathway.
131	27216364	Increased expression of SLK in GECs (following transfection) induced HSF1 transcriptional activity.
132	27216364	Moreover, HSF1 transcriptional activity was increased by in vitro ischemia-reperfusion injury (chemical anoxia/recovery) and heat shock, and in both instances was amplified further by SLK overexpression.
133	27216364	HSF1 binds to promoters of target genes, such as Hsp70 and induces their transcription.
134	27216364	By analogy to HSF1, SLK stimulated Hsp70 expression.
135	27216364	Hsp70 was also enhanced by anoxia/recovery and was further amplified by SLK overexpression.
136	27216364	Induction of HSF1 and Hsp70 was dependent on the kinase activity of SLK, and was mediated via polo-like kinase-1.
137	27216364	Transfection of constitutively active HSF1 enhanced Hsp70 expression and inhibited SLK-induced apoptosis.
138	27216364	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-μ.
139	27216364	In conclusion, increased expression/activity of SLK activates the HSF1-Hsp70 pathway.
140	27216364	Hsp70 attenuates the primary proapoptotic effect of SLK.
141	27216364	Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.
142	27216364	When highly expressed, SLK signals via c-Jun N-terminal kinase and p38 to induce apoptosis, and it exacerbates apoptosis induced by ischemia-reperfusion injury.
143	27216364	We address the interaction of SLK with the heat shock factor 1 (HSF1)-Hsp70 pathway.
144	27216364	Increased expression of SLK in GECs (following transfection) induced HSF1 transcriptional activity.
145	27216364	Moreover, HSF1 transcriptional activity was increased by in vitro ischemia-reperfusion injury (chemical anoxia/recovery) and heat shock, and in both instances was amplified further by SLK overexpression.
146	27216364	HSF1 binds to promoters of target genes, such as Hsp70 and induces their transcription.
147	27216364	By analogy to HSF1, SLK stimulated Hsp70 expression.
148	27216364	Hsp70 was also enhanced by anoxia/recovery and was further amplified by SLK overexpression.
149	27216364	Induction of HSF1 and Hsp70 was dependent on the kinase activity of SLK, and was mediated via polo-like kinase-1.
150	27216364	Transfection of constitutively active HSF1 enhanced Hsp70 expression and inhibited SLK-induced apoptosis.
151	27216364	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-μ.
152	27216364	In conclusion, increased expression/activity of SLK activates the HSF1-Hsp70 pathway.
153	27216364	Hsp70 attenuates the primary proapoptotic effect of SLK.
154	27216364	Ste20-like kinase, SLK, activates the heat shock factor 1 - Hsp70 pathway.
155	27216364	When highly expressed, SLK signals via c-Jun N-terminal kinase and p38 to induce apoptosis, and it exacerbates apoptosis induced by ischemia-reperfusion injury.
156	27216364	We address the interaction of SLK with the heat shock factor 1 (HSF1)-Hsp70 pathway.
157	27216364	Increased expression of SLK in GECs (following transfection) induced HSF1 transcriptional activity.
158	27216364	Moreover, HSF1 transcriptional activity was increased by in vitro ischemia-reperfusion injury (chemical anoxia/recovery) and heat shock, and in both instances was amplified further by SLK overexpression.
159	27216364	HSF1 binds to promoters of target genes, such as Hsp70 and induces their transcription.
160	27216364	By analogy to HSF1, SLK stimulated Hsp70 expression.
161	27216364	Hsp70 was also enhanced by anoxia/recovery and was further amplified by SLK overexpression.
162	27216364	Induction of HSF1 and Hsp70 was dependent on the kinase activity of SLK, and was mediated via polo-like kinase-1.
163	27216364	Transfection of constitutively active HSF1 enhanced Hsp70 expression and inhibited SLK-induced apoptosis.
164	27216364	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-μ.
165	27216364	In conclusion, increased expression/activity of SLK activates the HSF1-Hsp70 pathway.
166	27216364	Hsp70 attenuates the primary proapoptotic effect of SLK.
167	28475647	Regulation of Ste20-like kinase, SLK, activity: Dimerization and activation segment phosphorylation.
168	28475647	The Ste20-like kinase, SLK, has diverse cellular functions.
169	28475647	Regulation of Ste20-like kinase, SLK, activity: Dimerization and activation segment phosphorylation.
170	28475647	The Ste20-like kinase, SLK, has diverse cellular functions.
171	29187370	Ste20-like kinase, SLK, a novel mediator of podocyte integrity.
172	29187370	Podocyte number was reduced by 35% in knockout mice compared with control, and expression of nephrin, synaptopodin, and podocalyxin was reduced in knockout mice by 20-30%.
173	32308020	Ste20-like kinase SLK is critical for embryonic development and may play an important role in wound healing, muscle homeostasis, cell migration, and tumor growth.
174	32308020	Compared with control, SLK deletion exacerbated albuminuria and loss of podocytes, synaptopodin, and podocalyxin.
175	32308020	Ste20-like kinase SLK is critical for embryonic development and may play an important role in wound healing, muscle homeostasis, cell migration, and tumor growth.
176	32308020	Compared with control, SLK deletion exacerbated albuminuria and loss of podocytes, synaptopodin, and podocalyxin.