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Gene Information
Gene symbol: SOCS3
Gene name: suppressor of cytokine signaling 3
HGNC ID: 19391
Synonyms: SSI-3, CIS3, SOCS-3, Cish3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL6 | 1 hits |
| 2 | JAK2 | 1 hits |
| 3 | STAT3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 27522260 | The results demonstrated that the serum uric acid (Sur) level was significantly decreased by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) with astilbin, related with suppressing role in meditation of Glucose transporter 9 (GLUT9), Human urate transporter 1 (URAT1) expression and up-regulation of ABCG2, Organic anion transporter 1/3 (OAT1/3) and Organic cation transporter 1 (OCT1). |
| 2 | 27522260 | Further investigation indicated that astilbin prevented the renal damage against the expression of Thioredoxin-interacting protein (TXNIP) and its related inflammation signal pathway, including NLR pyrin domain-containing 3/Nuclear factor κB (NLRP3/NF-κB), which is associated with the up-regulation of interleukin-1β (IL-1β) and interleukin-18 (IL-18), and also presented a renal protective role by suppression oxidative stress. |
| 3 | 27522260 | Moreover, astilbin inhibited activation of the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) cascade and over-expression of suppressor of cytokine signaling 3 (SOCS3) in the kidneys of potassium oxonate-induced mice. |
| 4 | 24872191 | Suppressor of cytokine signaling 3 elicited the immunosuppressive actions of IL-6 in a process that disrupted the presentation of chemokines on GEnCs by altering the expression of the duffy Ag receptor for chemokines. |