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Gene Information

Gene symbol: SPINT1

Gene name: serine peptidase inhibitor, Kunitz type 1

HGNC ID: 11246

Synonyms: HAI, MANSC2

Related Genes

#	Gene Symbol	Number of hits
1	HGF	1 hits
2	NPHS2	1 hits
3	ST14	1 hits

Related Sentences

#	PMID	Sentence
1	32907879	Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury.
2	32907879	The mechanism could be accounted for by an imbalance favoring Matriptase over its cognate inhibitor, hepatocyte growth factor activator inhibitor type 1 (HAI-1), because conditional depletion of HAI-1 in podocytes accelerated podocyte injury in mouse model.
3	32907879	Matriptase was capable of cleaving Podocin, but such a reaction was blocked by either HAI-1 or dominant-negative Matriptase.
4	32907879	Furthermore, the N terminus of Podocin, as a consequence of Matriptase cleavage of Podocin, translocated to nucleoli, suggesting that the N terminus of Podocin might be involved in the process of podocyte injury.
5	32907879	Given these observations, we propose that the proteolytic cleavage of Podocin by Matriptase could potentially cause podocyte injury and that targeting Matriptase could be a novel therapeutic strategy for CKD patients.
6	32907879	Proteolytic cleavage of Podocin by Matriptase exacerbates podocyte injury.
7	32907879	The mechanism could be accounted for by an imbalance favoring Matriptase over its cognate inhibitor, hepatocyte growth factor activator inhibitor type 1 (HAI-1), because conditional depletion of HAI-1 in podocytes accelerated podocyte injury in mouse model.
8	32907879	Matriptase was capable of cleaving Podocin, but such a reaction was blocked by either HAI-1 or dominant-negative Matriptase.
9	32907879	Furthermore, the N terminus of Podocin, as a consequence of Matriptase cleavage of Podocin, translocated to nucleoli, suggesting that the N terminus of Podocin might be involved in the process of podocyte injury.
10	32907879	Given these observations, we propose that the proteolytic cleavage of Podocin by Matriptase could potentially cause podocyte injury and that targeting Matriptase could be a novel therapeutic strategy for CKD patients.