Ignet

Gene Information

Gene symbol: SPOP

Gene name: speckle-type POZ protein

HGNC ID: 11254

Synonyms: TEF2, BTBD32

Related Genes

#	Gene Symbol	Number of hits
1	NLRP3	1 hits
2	PARK2	1 hits

Related Sentences

#	PMID	Sentence
1	35081502	Spop ameliorates diabetic nephropathy through restraining NLRP3 inflammasome.
2	35081502	In the present study, an E3 ubiquitin ligase Speckle-type BTB-POZ protein (Spop) was identified as a suppressor of NLRP3 inflammasome.
3	35081502	Furthermore, Spop specific ablation in podocytes dramatically facilitated inflammatory response in glomeruli of DN mice via enhancing NLRP3 inflammasome and nuclear factor κB (NF-κB) signaling pathways, which were confirmed in HG-cultured podocytes.
4	35081502	Notably, our findings indicated that Spop directly interacted with NLRP3.
5	35081502	More importantly, Spop promoted NLRP3 degradation via elevating K48-linked polyubiquitination of NLRP3.
6	35081502	Collectively, our findings disclosed a mechanisms through which Spop limited NLRP3 inflammasome under HG condition, and illustrated that Spop may be a novel therapeutic target to suppress NLRP3 inflammasome, contributing to the DN management.
7	35081502	Spop ameliorates diabetic nephropathy through restraining NLRP3 inflammasome.
8	35081502	In the present study, an E3 ubiquitin ligase Speckle-type BTB-POZ protein (Spop) was identified as a suppressor of NLRP3 inflammasome.
9	35081502	Furthermore, Spop specific ablation in podocytes dramatically facilitated inflammatory response in glomeruli of DN mice via enhancing NLRP3 inflammasome and nuclear factor κB (NF-κB) signaling pathways, which were confirmed in HG-cultured podocytes.
10	35081502	Notably, our findings indicated that Spop directly interacted with NLRP3.
11	35081502	More importantly, Spop promoted NLRP3 degradation via elevating K48-linked polyubiquitination of NLRP3.
12	35081502	Collectively, our findings disclosed a mechanisms through which Spop limited NLRP3 inflammasome under HG condition, and illustrated that Spop may be a novel therapeutic target to suppress NLRP3 inflammasome, contributing to the DN management.
13	35081502	Spop ameliorates diabetic nephropathy through restraining NLRP3 inflammasome.
14	35081502	In the present study, an E3 ubiquitin ligase Speckle-type BTB-POZ protein (Spop) was identified as a suppressor of NLRP3 inflammasome.
15	35081502	Furthermore, Spop specific ablation in podocytes dramatically facilitated inflammatory response in glomeruli of DN mice via enhancing NLRP3 inflammasome and nuclear factor κB (NF-κB) signaling pathways, which were confirmed in HG-cultured podocytes.
16	35081502	Notably, our findings indicated that Spop directly interacted with NLRP3.
17	35081502	More importantly, Spop promoted NLRP3 degradation via elevating K48-linked polyubiquitination of NLRP3.
18	35081502	Collectively, our findings disclosed a mechanisms through which Spop limited NLRP3 inflammasome under HG condition, and illustrated that Spop may be a novel therapeutic target to suppress NLRP3 inflammasome, contributing to the DN management.
19	35081502	Spop ameliorates diabetic nephropathy through restraining NLRP3 inflammasome.
20	35081502	In the present study, an E3 ubiquitin ligase Speckle-type BTB-POZ protein (Spop) was identified as a suppressor of NLRP3 inflammasome.
21	35081502	Furthermore, Spop specific ablation in podocytes dramatically facilitated inflammatory response in glomeruli of DN mice via enhancing NLRP3 inflammasome and nuclear factor κB (NF-κB) signaling pathways, which were confirmed in HG-cultured podocytes.
22	35081502	Notably, our findings indicated that Spop directly interacted with NLRP3.
23	35081502	More importantly, Spop promoted NLRP3 degradation via elevating K48-linked polyubiquitination of NLRP3.
24	35081502	Collectively, our findings disclosed a mechanisms through which Spop limited NLRP3 inflammasome under HG condition, and illustrated that Spop may be a novel therapeutic target to suppress NLRP3 inflammasome, contributing to the DN management.
25	35081502	Spop ameliorates diabetic nephropathy through restraining NLRP3 inflammasome.
26	35081502	In the present study, an E3 ubiquitin ligase Speckle-type BTB-POZ protein (Spop) was identified as a suppressor of NLRP3 inflammasome.
27	35081502	Furthermore, Spop specific ablation in podocytes dramatically facilitated inflammatory response in glomeruli of DN mice via enhancing NLRP3 inflammasome and nuclear factor κB (NF-κB) signaling pathways, which were confirmed in HG-cultured podocytes.
28	35081502	Notably, our findings indicated that Spop directly interacted with NLRP3.
29	35081502	More importantly, Spop promoted NLRP3 degradation via elevating K48-linked polyubiquitination of NLRP3.
30	35081502	Collectively, our findings disclosed a mechanisms through which Spop limited NLRP3 inflammasome under HG condition, and illustrated that Spop may be a novel therapeutic target to suppress NLRP3 inflammasome, contributing to the DN management.
31	35081502	Spop ameliorates diabetic nephropathy through restraining NLRP3 inflammasome.
32	35081502	In the present study, an E3 ubiquitin ligase Speckle-type BTB-POZ protein (Spop) was identified as a suppressor of NLRP3 inflammasome.
33	35081502	Furthermore, Spop specific ablation in podocytes dramatically facilitated inflammatory response in glomeruli of DN mice via enhancing NLRP3 inflammasome and nuclear factor κB (NF-κB) signaling pathways, which were confirmed in HG-cultured podocytes.
34	35081502	Notably, our findings indicated that Spop directly interacted with NLRP3.
35	35081502	More importantly, Spop promoted NLRP3 degradation via elevating K48-linked polyubiquitination of NLRP3.
36	35081502	Collectively, our findings disclosed a mechanisms through which Spop limited NLRP3 inflammasome under HG condition, and illustrated that Spop may be a novel therapeutic target to suppress NLRP3 inflammasome, contributing to the DN management.