Ignet

Gene Information

Gene symbol: SULF1

Gene name: sulfatase 1

HGNC ID: 20391

Synonyms: KIAA1077, SULF-1

Related Genes

#	Gene Symbol	Number of hits
1	EGR1	1 hits
2	FGF2	1 hits
3	MAFF	1 hits
4	NPHS2	1 hits
5	NUDT6	1 hits
6	NXPH3	1 hits
7	PTPRO	1 hits
8	SCEL	1 hits
9	SULF2	1 hits
10	VEGFA	1 hits
11	WT1	1 hits

Related Sentences

#	PMID	Sentence
1	19797313	Scel, encoding sciellin, a protein of the cornified envelope in the skin, and Sulf1, encoding a 6-O endosulfatase, are shown to be expressed in wild-type podocytes and to be strongly down-regulated in mutants.
2	19797313	Co-expression of Wt1, Scel and Sulf1 was also found in a mesonephric cell line, and siRNA-mediated knockdown of WT1 decreased Scel and Sulf1 mRNAs and proteins.
3	19797313	By ChIP we show that Scel and Sulf1 are direct WT1 targets.
4	19797313	Cyp26a1 may play a role in the development of glomerular lesions but does not seem to be regulated by WT1.
5	19797313	Scel, encoding sciellin, a protein of the cornified envelope in the skin, and Sulf1, encoding a 6-O endosulfatase, are shown to be expressed in wild-type podocytes and to be strongly down-regulated in mutants.
6	19797313	Co-expression of Wt1, Scel and Sulf1 was also found in a mesonephric cell line, and siRNA-mediated knockdown of WT1 decreased Scel and Sulf1 mRNAs and proteins.
7	19797313	By ChIP we show that Scel and Sulf1 are direct WT1 targets.
8	19797313	Cyp26a1 may play a role in the development of glomerular lesions but does not seem to be regulated by WT1.
9	19797313	Scel, encoding sciellin, a protein of the cornified envelope in the skin, and Sulf1, encoding a 6-O endosulfatase, are shown to be expressed in wild-type podocytes and to be strongly down-regulated in mutants.
10	19797313	Co-expression of Wt1, Scel and Sulf1 was also found in a mesonephric cell line, and siRNA-mediated knockdown of WT1 decreased Scel and Sulf1 mRNAs and proteins.
11	19797313	By ChIP we show that Scel and Sulf1 are direct WT1 targets.
12	19797313	Cyp26a1 may play a role in the development of glomerular lesions but does not seem to be regulated by WT1.
13	21719793	WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier.
14	21719793	Here, we found that the transcription factor Wilms' Tumor 1 (WT1) modulates VEGFA and FGF2 signaling by increasing the expression of the 6-O-endosulfatases Sulf1 and Sulf2, which remodel the heparan sulfate 6-O-sulfation pattern in the extracellular matrix.
15	21719793	Mice deficient in both Sulf1 and Sulf2 developed age-dependent proteinuria as a result of ultrastructural abnormalities in podocytes and endothelial cells, a phenotype similar to that observed in children with WT1 mutations and in Wt1(+/-) mice.
16	21719793	Collectively, these data suggest that WT1-dependent sulfatase expression plays a critical role in maintaining the glomerular filtration barrier by modulating the bioavailability of growth factors, thereby promoting normal crosstalk between podocytes and endothelial cells.
17	21719793	WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier.
18	21719793	Here, we found that the transcription factor Wilms' Tumor 1 (WT1) modulates VEGFA and FGF2 signaling by increasing the expression of the 6-O-endosulfatases Sulf1 and Sulf2, which remodel the heparan sulfate 6-O-sulfation pattern in the extracellular matrix.
19	21719793	Mice deficient in both Sulf1 and Sulf2 developed age-dependent proteinuria as a result of ultrastructural abnormalities in podocytes and endothelial cells, a phenotype similar to that observed in children with WT1 mutations and in Wt1(+/-) mice.
20	21719793	Collectively, these data suggest that WT1-dependent sulfatase expression plays a critical role in maintaining the glomerular filtration barrier by modulating the bioavailability of growth factors, thereby promoting normal crosstalk between podocytes and endothelial cells.
21	30379099	We performed polysome analysis of intact and injured podocytes utilizing the NEP25 and RiboTag transgenic mice, in which a hemagglutinin tag is attached to ribosomal protein L22 selectively in podocytes.
22	30379099	Compared with glomerular cells, 353 genes were highly expressed and enriched in podocytes; these included important podocyte genes and also heretofore uncharacterized genes, such as Dach1 and Foxd2.
23	30379099	MafF and Egr-1, which structurally have the potential to antagonize MafB and WT1, respectively, were rapidly and markedly increased in injured podocytes before MafB and WT1 were decreased.
24	30379099	We demonstrated that Maff and Egr1 knockdown increased the MafB targets Nphs2 and Ptpro and the WT1 targets Ptpro, Nxph3, and Sulf1, respectively.
25	30379099	This indicates that upregulated MafF and Egr-1 may promote deterioration of podocytes by antagonizing MafB and WT1.