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Gene Information
Gene symbol: SYNPR
Gene name:
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DES | 1 hits |
| 2 | IGKV1-27 | 1 hits |
| 3 | NPHS1 | 1 hits |
| 4 | RPS27A | 1 hits |
| 5 | UCHL1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 30805933 | A20 overexpression exerts protective effects on podocyte injury in lupus nephritis by downregulating UCH-L1. |
| 2 | 30805933 | The study aims to explore the effect of A20 on LN in relation to the nuclear factor-kappa B (NF-κB) signaling pathway. |
| 3 | 30805933 | Next, A20, UCH-L1, and NF-κB expression in LN patients and MRL/lpr mice was determined. |
| 4 | 30805933 | A20 was downregulated, whereas UCH-L1 was upregulated in LN. |
| 5 | 30805933 | Overexpressed A20 declined NF-κB, UCH-L1 expression, and the extent of p65 phosphorylation. |
| 6 | 30805933 | A20 overexpression or UCH-L1 inhibition increased expression of synaptoporin and nephrin but decreased desmin expression and ubiquitin accumulation level in podocytes. |
| 7 | 30805933 | Moreover, A20 overexpression or UCH-L1 inhibition increased the podocyte number but decreased protein level of cleaved caspase-3, podocyte lesion improvement, decreased foot process width, glomerulus basement membrane, and foot process fusion rate. |
| 8 | 30805933 | In addition, urine protein, blood urea nitrogen, serum creatinine, and ds-DNA antibody levels decreased with elevated A20 or depleted UCH-L1. |
| 9 | 30805933 | Collectively, it could be concluded that A20 protects against podocyte injury in LN via UCH-L1 by inactivating the NF-κB signaling pathway. |