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Gene Information
Gene symbol: TEC
Gene name: tec protein tyrosine kinase
HGNC ID: 11719
Synonyms: PSCTK4
Related Genes
Related Sentences
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PMID |
Sentence |
1 |
12424224
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Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria.
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2 |
12424224
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Podocin interacts with the C-terminal domain of nephrin and facilitates nephrin-dependent signaling.
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3 |
12424224
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NEPH1 triggers AP-1 activation similarly to nephrin but requires the presence of Tec family kinases for efficient transactivation.
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4 |
12424224
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We conclude that NEPH1 defines a new family of podocin-binding molecules that are potential candidates for hereditary nephrotic syndromes not linked to either NPHS1 or NPHS2.
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