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Gene Information
Gene symbol: TGFBR2
Gene name: transforming growth factor, beta receptor II (70/80kDa)
HGNC ID: 11773
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | MIRN21 | 1 hits |
| 2 | PDCD4 | 1 hits |
| 3 | SMAD3 | 1 hits |
| 4 | SMAD7 | 1 hits |
| 5 | TGFB1 | 1 hits |
| 6 | TIMP3 | 1 hits |
| 7 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12545247 | Although in vitro studies suggest that TGF-beta(2) is equally potent to TGF-beta(1) in terms of its antimitogenic and fibrogenic effects, much less is known about the regulation of TGF-beta(2) in renal diseases associated with glomerular cell hyperplasia and matrix expansion. |
| 2 | 12545247 | Here we investigated the glomerular expression patterns of TGF-beta(2) and of the TGF-beta receptors I, II, and III during the course of rat anti-Thy1.1 nephritis (days 2, 6, 12, and 56), a model characterized by transient mesangial hypercellularity and extracellular matrix accumulation. |
| 3 | 12545247 | TGF-beta(2) exhibited dynamic changes in expression. |
| 4 | 12545247 | On day 6 of anti-Thy1.1 nephritis both TGF-beta(2) positive podocytes and mesangial cells were more abundant. |
| 5 | 12545247 | By western blot analysis of isolated glomeruli from nephritic rats, protein expression of TGF-beta(2) was upregulated tenfold over control glomeruli, peaking on day 6 of the disease. |
| 6 | 12545247 | In cultured rat mesangial cells we found that the TGF-beta(2) and TGF-beta(1) isoforms were equally potent in terms of nuclear accumulation of phosphorylated Smad 2/3, inhibition of DNA synthesis, and induction of beta(1)-integrin and type I collagen protein synthesis. |
| 7 | 12545247 | Expression of TGF-beta receptor II was strongly enhanced on days 6 and 12 of disease, while TGF-beta receptor III was upregulated only on day 6. |
| 8 | 12545247 | In summary, we report marked yet transient upregulation of TGF-beta(2) protein and of TGF-beta receptors I, II, and III in glomerular cells during anti-Thy1.1 nephritis. |
| 9 | 12545247 | These results are in keeping with the notion that TGF-beta(2) and its receptors participate in the pathogenesis and/or resolution of this transient form of glomerulonephritis. |
| 10 | 25145934 | In cultured podocytes, inhibition of miR-21 was accompanied by increases in the rate of cell death, TGF-β/Smad3-signaling activity, and expression of known proapoptotic miR-21 target genes p53, Pdcd4, Smad7, Tgfbr2, and Timp3. |
| 11 | 25145934 | In American-Indian patients with diabetic nephropathy (n=48), albumin-to-creatinine ratio was positively associated with miR-21 expression in glomerular fractions (r=0.6; P<0.001) but not tubulointerstitial fractions (P=0.80). |
| 12 | 25145934 | The aggravation of glomerular disease in miR-21-deficient mice and the positive association with albumin-to-creatinine ratio in patients with diabetic nephropathy support miR-21 as a feedback inhibitor of TGF-β signaling and functions. |