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Gene Information
Gene symbol: TICAM2
Gene name: toll-like receptor adaptor molecule 2
HGNC ID: 21354
Synonyms: TRAM, TICAM-2, TIRP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | NCK1 | 1 hits |
| 2 | NCK2 | 1 hits |
| 3 | NPHS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26802179 | Evidence indicates that tyrosine phosphorylation of the intracellular tail of nephrin initiates signaling events, including recruitment of cytoplasmic adaptor proteins Nck1 and Nck2 that regulate actin cytoskeletal dynamics. |
| 2 | 26802179 | To explore this possibility, we generated and analyzed knockin mice with mutations that disrupt nephrin tyrosine phosphorylation and Nck1/2 binding (nephrin(Y3F/Y3F) mice). |
| 3 | 31974115 | Assembly of signaling molecules into micrometer-sized clusters is driven by multivalent protein-protein interactions, such as those found within the nephrin-Nck (Nck1 or Nck2) complex. |
| 4 | 31974115 | Phosphorylation on multiple tyrosine residues within the tail of the nephrin transmembrane receptor induces recruitment of the cytoplasmic adaptor protein Nck, which binds via its triple SH3 domains to various effectors, leading to actin assembly. |
| 5 | 31974115 | We also reveal a connection between clustering and endocytosis, which appears to be driven by threshold levels of nephrin tyrosine phosphorylation and Nck SH3 domain signaling. |