Ignet

Gene Information

Gene symbol: TLN1

Gene name: talin 1

HGNC ID: 11845

Synonyms: ILWEQ

Related Genes

#	Gene Symbol	Number of hits
1	ACTN4	1 hits
2	CAPN1	1 hits
3	CAPN2	1 hits
4	NFATC1	1 hits
5	TGFA	1 hits
6	TRPC6	1 hits

Related Sentences

#	PMID	Sentence
1	31235574	The altered intracellular calcium homeostasis led to activation of calcium-dependent cytosolic protease calpain 2 and cleavage of its important downstream substrates, including the apoptotic molecule procaspase 12 and podocyte cytoskeletal protein talin 1.
2	33015191	Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes.
3	33015191	There was a significant increase in expression of transient receptor potential canonical channel 6 (TRPC6) and a decrease in expression of talin1 in podocytes of db/db mice.
4	33015191	Moreover, primary mice podocytes stimulated by AGEs displayed an increase in TRPC6-dependent Ca²⁺ influx, a loss of talin1, and translocation of nuclear factor of activated T cell (NFATC) 2.
5	33015191	In conclusion, TSF could protect podocytes from injury and reduce proteinuria in DKD, which may be mediated by the regulation of the TRPC6/Talin1 pathway in podocytes.
6	33015191	Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes.
7	33015191	There was a significant increase in expression of transient receptor potential canonical channel 6 (TRPC6) and a decrease in expression of talin1 in podocytes of db/db mice.
8	33015191	Moreover, primary mice podocytes stimulated by AGEs displayed an increase in TRPC6-dependent Ca²⁺ influx, a loss of talin1, and translocation of nuclear factor of activated T cell (NFATC) 2.
9	33015191	In conclusion, TSF could protect podocytes from injury and reduce proteinuria in DKD, which may be mediated by the regulation of the TRPC6/Talin1 pathway in podocytes.
10	33015191	Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes.
11	33015191	There was a significant increase in expression of transient receptor potential canonical channel 6 (TRPC6) and a decrease in expression of talin1 in podocytes of db/db mice.
12	33015191	Moreover, primary mice podocytes stimulated by AGEs displayed an increase in TRPC6-dependent Ca²⁺ influx, a loss of talin1, and translocation of nuclear factor of activated T cell (NFATC) 2.
13	33015191	In conclusion, TSF could protect podocytes from injury and reduce proteinuria in DKD, which may be mediated by the regulation of the TRPC6/Talin1 pathway in podocytes.
14	33015191	Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes.
15	33015191	There was a significant increase in expression of transient receptor potential canonical channel 6 (TRPC6) and a decrease in expression of talin1 in podocytes of db/db mice.
16	33015191	Moreover, primary mice podocytes stimulated by AGEs displayed an increase in TRPC6-dependent Ca²⁺ influx, a loss of talin1, and translocation of nuclear factor of activated T cell (NFATC) 2.
17	33015191	In conclusion, TSF could protect podocytes from injury and reduce proteinuria in DKD, which may be mediated by the regulation of the TRPC6/Talin1 pathway in podocytes.
18	34878723	Interestingly, α-actinin-4 and talin-1 proteolytic fragments were detected in brain death but not in circulatory death or living donor kidneys with similar donor characteristics.
19	34878723	As talin-1 is a specific proteolytic target of calpain-1, we investigated a potential trigger of calpain activation and talin-1 degradation using human ex vivo precision-cut kidney slices and in vitro podocytes.
20	34878723	Notably, we showed that activation of calpain-1 by transforming growth factor-β generated proteolytic fragments of talin-1 that matched the degradation fragments detected in DBD preimplantation kidneys, also causing dysregulation of the actin cytoskeleton in human podocytes; events that were reversed by calpain-1 inhibition.
21	34878723	Interestingly, α-actinin-4 and talin-1 proteolytic fragments were detected in brain death but not in circulatory death or living donor kidneys with similar donor characteristics.
22	34878723	As talin-1 is a specific proteolytic target of calpain-1, we investigated a potential trigger of calpain activation and talin-1 degradation using human ex vivo precision-cut kidney slices and in vitro podocytes.
23	34878723	Notably, we showed that activation of calpain-1 by transforming growth factor-β generated proteolytic fragments of talin-1 that matched the degradation fragments detected in DBD preimplantation kidneys, also causing dysregulation of the actin cytoskeleton in human podocytes; events that were reversed by calpain-1 inhibition.
24	34878723	Interestingly, α-actinin-4 and talin-1 proteolytic fragments were detected in brain death but not in circulatory death or living donor kidneys with similar donor characteristics.
25	34878723	As talin-1 is a specific proteolytic target of calpain-1, we investigated a potential trigger of calpain activation and talin-1 degradation using human ex vivo precision-cut kidney slices and in vitro podocytes.
26	34878723	Notably, we showed that activation of calpain-1 by transforming growth factor-β generated proteolytic fragments of talin-1 that matched the degradation fragments detected in DBD preimplantation kidneys, also causing dysregulation of the actin cytoskeleton in human podocytes; events that were reversed by calpain-1 inhibition.