Ignet

Gene Information

Gene symbol: TNFRSF11A

Gene name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator

HGNC ID: 11908

Synonyms: RANK, CD265

Related Genes

#	Gene Symbol	Number of hits
1	NFKB1	1 hits
2	TNFRSF11B	1 hits
3	TNFSF11	1 hits

Related Sentences

#	PMID	Sentence
1	25171769	Biochemical, clinical and experimental procedures included measurement of total urinary protein, renal biopsy and gene expression analysis of the receptor activator of NF-kappaB (RANK).
2	26459042	The mRNA expressions levels of FAK, RANKL, p38, extracellular signal‑regulated kinase (ERK), c‑Jun N‑terminal kinase (JNK), and nephrin were then quantified by reverse transcription‑quantitative polymerase chain reaction.
3	26459042	In addition, the protein expressions levels of FAK, RANKL, p38, ERK, JNK, phosphorylated (p)‑FAK, p‑ERK, and p‑JNK were quantified by western blotting.
4	26459042	As compared with the normal group, the protein expression levels of FAK, RANKL, p-FAK, p38 and p-ERK in the model group were increased.
5	26459042	In the prednisone group, the urinary protein levels, the protein expression levels of FAK, RANKL, p38, p-FAK, p-p38 and the mRNA expression levels of FAK, p38, RANKL, ERK, JNK decreased, as compared with the model group.
6	26459042	In the prednisone group, the mRNA and protein expression levels of nephrin and the serum expression levels of RANKL increased, the serum expression levels of osteoprotegerin (OPG) were decreased, as compared with the model group.
7	26459042	These results suggested that prednisone is able to protect podocytes from apoptosis, and reduce urinary protein levels by inhibiting the FAK/RANKL/MAPK signaling pathway in kidney tissue samples.
8	26459042	Serum prednisone may induce osteoporosis via the OPG/RANK/RANKL signaling pathway.
9	26880862	However, the expression and the potential roles of RANKL and RANK in diabetic nephropathy (DN) remain unclear.
10	26880862	Our present study investigated the effects of Irb in DN and whether the renal protective effects of Irb are mediated by RANKL/RANK and the downstream NF-κB pathway in db/db mice.
11	26880862	At the molecular level, RANKL and RANK were overexpressed in the kidneys of db/db mice and Irb downregulated RANKL and RANK and inhibited the downstream NF-κB pathway.
12	26880862	However, the expression and the potential roles of RANKL and RANK in diabetic nephropathy (DN) remain unclear.
13	26880862	Our present study investigated the effects of Irb in DN and whether the renal protective effects of Irb are mediated by RANKL/RANK and the downstream NF-κB pathway in db/db mice.
14	26880862	At the molecular level, RANKL and RANK were overexpressed in the kidneys of db/db mice and Irb downregulated RANKL and RANK and inhibited the downstream NF-κB pathway.
15	26880862	However, the expression and the potential roles of RANKL and RANK in diabetic nephropathy (DN) remain unclear.
16	26880862	Our present study investigated the effects of Irb in DN and whether the renal protective effects of Irb are mediated by RANKL/RANK and the downstream NF-κB pathway in db/db mice.
17	26880862	At the molecular level, RANKL and RANK were overexpressed in the kidneys of db/db mice and Irb downregulated RANKL and RANK and inhibited the downstream NF-κB pathway.
18	27052152	Cyclopropanyldehydrocostunolide LJ attenuates high glucose-induced podocyte injury by suppressing RANKL/RANK-mediated NF-κB and MAPK signaling pathways.
19	32993539	A case of minimal change disease after the administration of anti receptor activator of nuclear factor kappa B ligand (RANKL) monoclonal antibody: a case report.