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Gene Information
Gene symbol: VAMP2
Gene name: vesicle-associated membrane protein 2 (synaptobrevin 2)
HGNC ID: 12643
Synonyms: VAMP-2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | NPHS1 | 1 hits |
| 3 | ORAI1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17395751 | Nephrin is critical for the action of insulin on human glomerular podocytes. |
| 2 | 17395751 | Knocking nephrin down with siRNA in wild-type podocytes abrogated the insulin response, and stable nephrin transfection of nephrin-deficient podocytes rescued their insulin response. |
| 3 | 17395751 | Mechanistically, we show that nephrin allows the GLUT1- and GLUT4-rich vesicles to fuse with the membrane of this cell. |
| 4 | 17395751 | Furthermore, we show that the COOH of nephrin interacts with the vesicular SNARE protein VAMP2 in vitro and ex vivo (using yeast-2 hybrid and coimmunoprecipitation studies). |
| 5 | 17395751 | This work demonstrates a previously unsuspected role of nephrin in vesicular docking and insulin responsiveness of podocytes. |
| 6 | 34764278 | Here, we demonstrated that insulin stimulates SOCE by VAMP2-dependent Orai1 trafficking to the plasma membrane. |
| 7 | 34764278 | Insulin-activated SOCE triggers actin remodeling and transepithelial albumin leakage via the Ca2+-calcineurin pathway in podocytes. |
| 8 | 34764278 | Conversely, podocyte-specific Orai1 deletion prevents insulin-stimulated SOCE, synaptopodin depletion, and proteinuria. |