Ignet

Gene Information

Gene symbol: VWF

Gene name: von Willebrand factor

HGNC ID: 12726

Related Genes

#	Gene Symbol	Number of hits
1	ADAMTS13	1 hits
2	CADM1	1 hits
3	CD24	1 hits
4	CDH17	1 hits
5	ESAM	1 hits
6	ICAM2	1 hits
7	KDR	1 hits
8	MCAM	1 hits
9	NPHS2	1 hits
10	PECAM1	1 hits
11	PROM1	1 hits
12	SCARA5	1 hits
13	THY1	1 hits
14	VEGFA	1 hits

Related Sentences

#	PMID	Sentence
1	31881024	Using double immunofluorescence (IF) followed by digital image analysis, kidney sections were stained for fibrin(ogen) and CD41 (marker for platelets), von-Willebrand factor (marker for endothelial cells and platelets), and podocin (marker for podocytes).
2	31126000	The scavenger receptor SCARA5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen.
3	19579288	We found that human glomeruli deprived of the Bowman's capsule contain a population of CD133+CD146+ cells and a population of CD133-CD146+ cells expressing mesenchymal stem cell (MSC) markers and renal stem cell markers CD24 and Pax-2.
4	19579288	The CD133+CD146+ cells differed from those previously isolated from Bowman's capsule as they co-expressed endothelial markers, such as CD31 and von Willebrand factor (vWF), were CD24-negative and were not clonogenic, suggesting an endothelial commitment.
5	19579288	In addition to osteogenic, adipogenic, and chondrogenic differentiation, these cells were able to differentiate to endothelial cells and epithelial cells expressing podocytes markers such as nephrin, podocin, and synaptopodin.
6	19579288	Moreover, Gl-MSC when cultured in appropriate conditions, acquired mesangial cell markers such as alpha-smooth muscle actin (alpha-SMA) and angiotensin II (AT-II) receptor I.
7	17627784	Cultured human podocytes expressed ADAMTS13 mRNA and protein, and podocyte lysate exhibited von Willebrand factor-cleaving activity.
8	16557232	Cells were selected, cloned, and then characterized by light and electron microscopy (EM), response to vascular endothelial growth factor (VEGF), and tumour necrosis factor (TNF)alpha, expression of endothelial markers by focused gene array, immunofluorescence and Western blotting, and formation and behaviour of monolayers.
9	16557232	EM demonstrated fenestrations, increased in number by VEGF. mRNA analysis confirmed expression of the endothelial markers platelet endothelial cell adhesion molecule 1, intercellular adhesion molecule 2, VEGF receptor 2, and von Willebrand factor, validated by immunofluorescence and Western blotting.
10	16557232	CiGEnC also expressed Tie2, and TNFalpha upregulated E-selectin.
11	11456410	The arborized cells from decapsulated glomeruli showed intense staining for a podocyte-specific marker, podocalyxin, but no staining for markers specific to PECs (pan cadherin), mesangial cells (Thy-1) or endothelial cells (von Willebrand factor, RECA-1), indicating their podocyte origin.
12	11456410	Thus, the cell population from decapsulated glomeruli is distinctly different from that from encapsulated glomeruli, supporting the idea that polygonal cells originate from PECs, although immunocytochemical markers specific to podocytes in vivo such as WT1, synaptopodin, HSP27 and P-31 antigen were expressed significantly in the polygonal cells.
13	9621286	The ability of VEGF to be chemotactic for monocytes and to increase the activity of collagenase and plasminogen activator may have implications for renal development and renal disease.
14	9621286	In humans, the cellular actions of VEGF depend on binding to two specific receptors: Flt-1 and KDR.
15	9621286	The aims of this study were: (1) to localize VEGF receptor proteins in human renal ontogenesis; (2) to quantify VEGF binding in human fetal and adult kidney; and (3) to dissect the binding into its two known components: the KDR and Flt-1 receptors.
16	9621286	The latter aim was achieved by competitive binding of VEGF and placenta growth factor-2, which only binds to Flt-1.
17	9621286	By double-label immunohistochemistry, VEGF receptor proteins were localized solely to endothelial cells of preglomerular vessels, glomeruli, and postglomerular vessels.
18	9621286	In developing glomeruli, VEGF receptor protein appeared as soon as endothelial cells were positive for von Willebrand factor.
19	9621286	Placenta growth factor-2 displaced VEGF binding in all renal structures by approximately 60%.
20	9621286	VEGF receptor proteins thus were found only in renal endothelial cells.
21	9621286	A coexpression of both VEGF binding sites could be shown, with Flt-1 demonstrating the most abundant VEGF receptor binding sites in the kidney.