- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: WAS
Gene name: Wiskott-Aldrich syndrome
HGNC ID: 12731
Synonyms: WASP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACTR2 | 1 hits |
| 2 | NCK1 | 1 hits |
| 3 | NPHS1 | 1 hits |
| 4 | NTRK3 | 1 hits |
| 5 | WASF1 | 1 hits |
| 6 | WASL | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20484117 | Moreover, c-mip inhibited interactions between Fyn and the cytoskeletal regulator N-WASP (neural Wiskott-Aldrich syndrome protein) and between the adaptor protein Nck and nephrin, potentially accounting for cytoskeletal disorganization and the effacement of foot processes seen in idiopathic nephrotic syndromes. |
| 2 | 23471198 | Here, we demonstrate that neuronal Wiskott-Aldrich syndrome protein (N-WASP), which promotes actin nucleation, is required to stabilize podocyte foot processes. |
| 3 | 29162704 | Tropomyosin-related kinase C (TrkC) enhances podocyte migration by ERK-mediated WAVE2 activation. |
| 4 | 29162704 | Activation of endogenous TrkC by its ligand neurotrophin-3 resulted in increased podocyte migration-a surrogate of podocyte actin dynamics in vivo. |
| 5 | 29162704 | Employing a mutagenesis approach, we found that the Src homologous and collagen-like (Shc) binding site Tyr516 within the TrkC cytoplasmic domain was necessary for TrkC-induced migration of podocytes. |
| 6 | 29162704 | TrkC activation led to a mobility shift of Wiskott-Aldrich syndrome family verprolin-homologous protein (WAVE)-2 which is known to orchestrate Arp2/3 activation and actin polymerization. |
| 7 | 29162704 | Chemical inactivation of Erk or mutagenesis of 2 of 4 known Erk target sites within WAVE2, Thr346 and Ser351, abolished the TrkC-induced WAVE2 mobility shift. |
| 8 | 29162704 | Knockdown of WAVE2 by shRNA abolished TrkC-induced podocyte migration. |
| 9 | 29162704 | In summary, TrkC signals to the podocyte actin cytoskeleton to induce migration by phosphorylating WAVE2 Erk dependently. |