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Gene Information
Gene symbol: WASF1
Gene name: WAS protein family, member 1
HGNC ID: 12732
Synonyms: WAVE1, SCAR1, KIAA0269, WAVE
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACTR2 | 1 hits |
| 2 | NTRK3 | 1 hits |
| 3 | SYNPO | 1 hits |
| 4 | WAS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26634693 | WAVE1 overexpression and synaptopodin knockdown experiments directly demonstrated that WAVE1 expression is not dependent on synaptopodin expression, and vice versa. |
| 2 | 29162704 | Tropomyosin-related kinase C (TrkC) enhances podocyte migration by ERK-mediated WAVE2 activation. |
| 3 | 29162704 | Activation of endogenous TrkC by its ligand neurotrophin-3 resulted in increased podocyte migration-a surrogate of podocyte actin dynamics in vivo. |
| 4 | 29162704 | Employing a mutagenesis approach, we found that the Src homologous and collagen-like (Shc) binding site Tyr516 within the TrkC cytoplasmic domain was necessary for TrkC-induced migration of podocytes. |
| 5 | 29162704 | TrkC activation led to a mobility shift of Wiskott-Aldrich syndrome family verprolin-homologous protein (WAVE)-2 which is known to orchestrate Arp2/3 activation and actin polymerization. |
| 6 | 29162704 | Chemical inactivation of Erk or mutagenesis of 2 of 4 known Erk target sites within WAVE2, Thr346 and Ser351, abolished the TrkC-induced WAVE2 mobility shift. |
| 7 | 29162704 | Knockdown of WAVE2 by shRNA abolished TrkC-induced podocyte migration. |
| 8 | 29162704 | In summary, TrkC signals to the podocyte actin cytoskeleton to induce migration by phosphorylating WAVE2 Erk dependently. |