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Gene Information
Gene symbol: WISP1
Gene name: WNT1 inducible signaling pathway protein 1
HGNC ID: 12769
Synonyms: CCN4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CTGF | 1 hits |
| 2 | CYR61 | 1 hits |
| 3 | NOV | 1 hits |
| 4 | WISP2 | 1 hits |
| 5 | WISP3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 29506624 | CCN3, a key matricellular protein, distinctly inhibits TGFβ1-mediated Smad1/5/8 signalling in human podocyte culture. |
| 2 | 29506624 | CCN3 is a member of CCN family which also comprises CCN1 (CYR61), CCN2 (CTGF), CCN4 (WISP-1), CCN5 (WISP-2) and CCN6 (WISP-3). |
| 3 | 29506624 | CCN3 has been shown to antagonise CTGF. |
| 4 | 29506624 | Real time PCR was performed to look for gene expression of Fn and collagen IV and collagen I. |
| 5 | 29506624 | TGFβ1 induced the Smad1/5/8, Smad3 and p38 phosphorylation and CCN3 downregulated the TGFβ1 induced Smad1/5/8 phosphorylation and did not affect Smad3 and p38 phosphorylation. |
| 6 | 29506624 | CCN3 also induced collagen IV, Collagen I and Fn gene expression. |
| 7 | 29506624 | This is the first evidence of downregulation of TGFβ-mediated activation of a Smad1/5/8 signalling pathway by CCN3 in human podocytes and in any cell type. |