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Gene Information
Gene symbol: WNT6
Gene name: wingless-type MMTV integration site family, member 6
HGNC ID: 12785
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ATF3 | 1 hits |
| 2 | FZD9 | 1 hits |
| 3 | JUP | 1 hits |
| 4 | NFATC1 | 1 hits |
| 5 | WNT1 | 1 hits |
| 6 | WNT2B | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 26539236 | Cellular experiments in vitro showed that curcumin significantly antagonized leptin-induced downregulation of the mRNA and protein expression of podocyte-associated molecules including nephrin, podocin, podoplanin, and podocalyxin. |
| 2 | 26539236 | Furthermore, the experiments in vitro and in vivo both displayed that curcumin could downregulate the mRNA and protein expressions of Wnt1, Wnt2b, Wnt6, and β-catenin and upregulate the phosphorylation level of β-catenin protein in podocytes and renal tissue. |
| 3 | 29038896 | Compared with the control (C57 or BKS), ATF3 expression was elevated in animal model of proteinuria (LPS-treated C57 mice) and the model of diabetic nephropathy (db/db mice). |
| 4 | 29038896 | Overexpression of ATF3 increased podocyte apoptosis and decreased expression of podocin, the cell marker of podocyte; in contrast, ATF3-small interfering RNA knockdown reduced podocyte apoptosis and increased podocin expression. |
| 5 | 29038896 | ATF3 directly modulates the regulation of NFATc1 gene promoter activity and alters the expression of Wnt6 and Fzd9, direct target genes of NFATc1 signaling. |
| 6 | 29038896 | The ATF3 binding site of NFATc1 gene promoter is located at the region 671-775 base pairs upstream of the transcription start site. |