Ignet

Gene Pair: ARHGEF1, CCL16

Related Sentences

#	PMID	Sentence
1	20562522	Cell death of LSCs and LECs is essential for structural luteolysis.
2	20562522	We previously reported that a treatment combining tumor necrosis factor α (TNF) and interferon γ (IFNG) induced cell death in LSCs and that LECs express TNF receptor type I (TNFRI).
3	20562522	To induce cell death in LECs, LECs were treated with TNF or IFNG (0, 0.05, 0.5, 1.0, 2.5 nM) and a combination of TNF (0.5 nM) and IFNG (0.5 nM) for 24 h.
4	20562522	The viability of LECs was reduced by a single treatment with TNF or IFNG dose-dependently (P<0.05).
5	20562522	Cell viability was further decreased by treatment with a combination of TNF and IFNG (P<0.05).
6	20562522	Cells with DNA fragmentation (TUNEL-positive cells) were observed after the treatment with TNF and IFNG.
7	20562522	Semi-quantitative RT-PCR analysis revealed that treatment with IFNG alone or in combination with TNF increased the expression of TNFRI mRNA compared with the control (P<0.05).
8	20562522	In summary, TNF and IFNG increased cell death in cultured bovine LECs.
9	20562522	The upregulation of TNFRI mRNA expression by IFNG suggests that TNF and IFNG synergistically affect the death of LECs resulting in acute luteolysis.