| # |
PMID |
Sentence |
| 1 |
2113589
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When used in combination with interferon gamma (IFNG) or chemotherapeutic drugs targeted at DNA topoisomerase II, synergistic cytotoxicity has been observed.
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| 2 |
2113589
|
The cytotoxicity of TNF and low dose actinomycin-D (AMD) against MBT-2 in vitro was examined alone and following preincubation with IFNG.
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| 3 |
2113589
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The activity of TNF/AMD in vivo utilizing an intravesical implantation mode (MBT-2) was also evaluated.
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| 4 |
2113589
|
TNF/AMD was cytotoxic for MBT-2 growth in vitro.
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| 5 |
2113589
|
A two hour preincubation with IFNG markedly increased the cytotoxicity of TNF/AMD whereas longer incubations did not enhance cytotoxic activity.
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| 6 |
2113589
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This study demonstrated that TNF/AMD exhibits cytotoxicity for MBT-2 cells in vitro but is ineffective in reducing implantation of intravesical tumors in vivo.
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| 7 |
2113589
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The in vitro data suggest brief exposure of MBT-2 cells to IFNG augments the subsequent anti-tumor activity of TNF/AMD.
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