Ignet

Gene Pair: MICA, KLRK1

Related Sentences

#	PMID	Sentence
1	15490153	MHC class I chain-related gene A (MICA), a putative independent susceptibility gene in autoimmune diseases, encodes a surface protein present in epithelial cells that binds to NKG2D, an activating receptor of NK, alphabeta and gammadelta T cells, and could function as a stress-inducible activator of the innate immune response.
2	15490153	Total RNA was purified and MICA, IFNG and NKG2D mRNA were quantified by fluorescent real-time RT-PCR.
3	15490153	MICA expression was detected in both patients and controls, but incubation with gliadin induced a strong increase in samples from the treated CD group compared with the non-CD controls (P=0.028), while no differences were observed for IFNG or NKG2D mRNA levels.
4	21893449	Premalignant quiescent melanocytic nevi do not express the MHC class I chain-related protein A.
5	21893449	The MHC class I chain-related protein A (MICA) is an inducible molecule almost not expressed by normal cells but strongly up-regulated in tumor cells.
6	21893449	MICA-expressing cells are recognized by natural killer (NK) cells, CD8+ abTCR and gdTCR T lymphocytes through the NKG2D receptor.
7	21893449	Engagement of NKG2D by MICA triggers IFN-g secretion and cytotoxicity against malignant cells.