Ignet

Gene Pair: STAT4, NFKBIZ

Related Sentences

#	PMID	Sentence
1	20876105	IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18.
2	20876105	Analysis of Nfkbiz(-/-) mice revealed that IκBζ was essential for the production of IFN-γ production and cytotoxic activity in NK cells in response to IL-12 and/or IL-18 stimulation.
3	20876105	IL-12/IL-18-mediated gene induction was profoundly impaired in Nfkbiz(-/-) NK cells.
4	20876105	Whereas the phosphorylation of STAT4 was normally induced by IL-12 stimulation, STAT4 was not recruited to the Ifng gene regions in Nfkbiz(-/-) NK cells.
5	20876105	Acetylation of histone 3 K9 on Ifng regions was also abrogated in Nfkbiz(-/-) NK cells.
6	20876105	IκBζ was recruited on the proximal promoter region of the Ifng gene, and overexpression of IκBζ together with IL-12 activated the Ifng promoter.