Ignet

Gene Pair: BCAR1, VCL

Related Sentences

#	PMID	Sentence
1	11553524	CD2AP and p130Cas localize to different F-actin structures in podocytes.
2	11553524	Mice lacking the 80-kDa CD2-associated protein (CD2AP) develop progressive renal failure that starts soon after birth with proteinuria and foot process effacement by unknown mechanisms.
3	11553524	CD2AP has been identified and cloned independently by virtue of its interaction with the T cell protein CD2 and with the docking protein p130Cas.
4	11553524	In the present study we examined the localization of CD2AP and p130Cas in the mouse glomerulus and in cultured podocytes.
5	11553524	In glomeruli, CD2AP and p130Cas immunofluorescence were observed in podocytes, where they colocalized with F-actin in foot processes.
6	11553524	In cultured podocytes, p130Cas was enriched at sites of focal adhesions, where it colocalized like vinculin with F-actin at stress fiber ends.
7	11553524	The spot-shaped F-actin structures were also stained by antibodies against the actin nucleation Arp2/3 complex and cortactin, both contributing to dynamic actin assembly.
8	11553524	Moreover, CD2AP spots in cultured podocytes were in close spatial association with actinin-4, but not actinin-1.
9	11553524	Our results suggest that CD2AP and p130Cas, which both colocalize with F-actin in podocytes in situ, possess different functions.
10	11553524	Whereas p130Cas is found in focal adhesions, CD2AP seems to be involved in the regulation of highly dynamic F-actin structures in podocyte foot processes.