Ignet

Gene Pair: CDKN1A, WT1

Related Sentences

#	PMID	Sentence
1	9108440	Induction of p21 by the Wilms' tumor suppressor gene WT1.
2	9108440	We have recently shown that inducible expression of WT1 in osteosarcoma cells triggers programmed cell death, an effect that is associated with transcriptional repression of the endogenous epidermal growth factor receptor.
3	9108440	We now show that WT1-mediated apoptosis is preceded by induction of the cyclin-dependent kinase inhibitor p21, associated with G1 phase arrest.
4	9108440	This effect is only demonstrated by WT1 isoforms with an intact DNA binding domain, and it is associated with increased expression of endogenous p21 mRNA.
5	9108440	WT1-mediated induction of p21 is independent of p53, another tumor suppressor gene known to regulate p21 expression.
6	9108440	In the kidney, p21 is expressed in differentiating glomerular podocytes along with WT1.
7	9108440	We conclude that induction of p21 expression may contribute to WT1-dependent differentiation pathways in the kidney and potentially to the function of WT1 as a tumor suppressor gene.