Ignet

Gene Pair: COL1A1, ACTA1

Related Sentences

#	PMID	Sentence
1	11174028	Renal and vascular injury induced by exogenous angiotensin II is AT1 receptor-dependent.
2	11174028	We also examined the role of the local renin-angiotensin system (RAS) by examining the expression of angiotensin-converting enzyme (ACE) and the effect of treatment with the ACE inhibitor, ramipril.
3	11174028	Renal injury was manifested by proteinuria, glomerular phenotypic changes (mesangial expression of alpha-actin and podocyte expression of desmin), and tubulointerstitial injury with the tubular upregulation of the macrophage-adhesive protein, osteopontin, the interstitial accumulation of macrophages and myofibroblasts, and the deposition of collagen types III and IV.
4	11174028	Ang II infusion decreased AT1 receptor number in the renal interstitium but not in glomeruli.
5	11174028	Ang II infusion was also associated with an increase in ACE protein in both the proximal tubular brush border as well as at interstitial sites of injury, but despite evidence for activation of the local RAS, treatment with ramipril was without effect.
6	11174028	These studies demonstrate that the renal and vascular injury induced by Ang II infusion is mediated by the AT1 receptor despite downregulation of the receptor in the interstitium.