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PMID |
Sentence |
| 1 |
8200474
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Analysis of the fibroblast growth factor-2 (FGF-2 or bFGF) proteins during chicken embryonic pattern formation and organogenesis revealed that three isoforms (18.5, 20.0, and 21.5 kDa) were synthesized by alternative translation initiation from one coding region.
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| 2 |
8995747
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Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy.
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| 3 |
8995747
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In the present study, two series of experiments were done with PAN nephropathy rats given fibroblast growth factor 2 (FGF2) or FGF2 neutralizing antibodies.
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| 4 |
8995747
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In the first series of experiments, a dose of 10 micrograms of FGF2 (FGF2 group), 40 micrograms of an FGF2 neutralizing antibody (Anti-FGF2 group) or an equal volume of physiological saline (Control group) was administered for four days after PAN injection.
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| 5 |
8995747
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Urinary protein increased more in the FGF2 group than in the other two groups.
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| 6 |
8995747
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PCNA (+) glomerular cells were found in decreasing order in groups FGF2, Control and Anti-FGF2.
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| 7 |
8995747
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Staining for desmin, a marker of podocyte injury, was significantly reduced in the Anti-FGF2 group.
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| 8 |
8995747
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Glomerular adhesive lesions were found in decreasing order in groups FGF2, Control and Anti-FGF2.
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| 9 |
8995747
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The second series of experiments was designed to study the effects of FGF2 neutralizing antibody (40 micrograms for 5 days after PAN injection, in MoAb group) on severely damaged podocytes caused by repeated (two courses) injections in the PAN nephropathy rats.
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| 10 |
8995747
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It was supposed that FGF2 would promote the formation of adhesive lesions by stimulating the proliferation of podocytes and epithelial cells of Bowman's capsule.
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| 11 |
8995747
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Additionally, FGF2 itself was thought to impair podocytes because of the increasing desmin score and proteinuria.
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| 12 |
11591823
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To examine the potential role of fibroblast growth factor (FGF) signalling during cell differentiation, we used conditionally immortalised podocyte cells isolated from kidneys of Fgf2 mutant and wild-type mice.
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| 13 |
11591823
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Wild-type mouse podocyte cells upregulate FGF2 expression when differentiating in culture, as do maturing podocytes in vivo.
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| 14 |
11591823
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Molecular analysis of Fgf2 mutant mouse podocyte cells reveals a general disruption of FGF signalling as expression of Fgf7 and Fgf10 are also downregulated.
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