Ignet

Gene Pair Information

Gene Pair: PTHR1, PTH

Related Sentences

#	PMID	Sentence
1	8769838	Localization of parathyroid hormone/parathyroid hormone-related peptide receptor mRNA in kidney.
2	8769838	To define cells expressing receptors for PTH in kidney, we localized PTH/ PTH-related peptide (PTH/PTHrP) receptor mRNA in rat kidney by in situ hybridization.
3	8769838	PTH/PTHrP receptor mRNA is localized to glomerular podocytes, convoluted and straight proximal tubules, the cortical portion of thick ascending limbs, and distal convoluted tubules, but was not detected in the thin limb of Henle's loop or in collecting ducts.
4	8769838	Northern blot analysis showed that cultured human glomerular podocytes express a unique 4.0-kb PTH/PTHrP receptor transcript but do not express detectable levels of the common approximately 2.4-kb transcript found in whole kidney and in many other tissues.
5	8769838	Whereas the tubular localization of PTH/PTHrP receptor mRNA coincides well with previously known sites of PTH action, the intense expression and the unique size of the PTH/PTHrP receptor transcript in glomerular podocytes suggest that PTH and/or PTHrP may play a role(s) in glomerular function.
6	8977437	The kidney is the major site of expression of the PTH/PTH-related peptide receptor (PTHR) gene.
7	8977437	Immunohistochemical and immunoelectron microscopic analysis showed that PTHR protein is expressed on both basolateral and luminal membranes of proximal tubular epithelial cells, strongly suggesting a bipolar mode of action of PTH.
8	9121603	The first receptor which has been cloned and well characterized is "PTH/PTHrP receptor-1".
9	9121603	It is activated not only by PTH, but also by PTH-related peptide (PTHrP), via a signal transduction system involving G-proteins, adenylate cyclase and phospholipase C.
10	9121603	One or several receptors are probably expressed in the keratinocyte and the glomerular podocyte which are not identical with PTH/ PTHrP receptor-1.
11	9121603	A third receptor, which has been cloned recently and called "PTH2 receptor", recognizes solely PTH.
12	9121603	There is also evidence for a fourth receptor, called "C-PTH receptor", recognizing C-terminal PTH fragments which are generally considered to be biologically inactive.
13	9121603	Down-regulation of PTH/PTHrP receptor-1 mRNA expression could explain the well-known resistance to the action of PTH in chronic renal failure.
14	9121603	A mutation of PTH/PTHrP receptor-1 causes Jansen-type metaphyseal chondrodysplasia.
15	9121603	However, no alteration of the PTH/PTHrP receptor-1 gene structure has been found in type 1b pseudohypoparathyroidism.