Ignet

Gene Pair: TEK, TIE1

Related Sentences

#	PMID	Sentence
1	11261688	Angiopoietin-1 (Ang-1) is a secreted growth factor which binds to and activates the Tie-2 receptor tyrosine kinase.
2	11261688	Ang-2 binds the same receptor but fails to activate it: hence, it is a natural inhibitor of Ang-1.
3	11261688	Ang-2 destabilises capillary integrity, facilitating sprouting when ambient vascular endothelial growth factor (VEGF) levels are high, but causing vessel regression when VEGF levels are low.
4	11261688	Tie-1 is a Tie-2 homologue but its ligands are unknown.
5	11261688	During glomerular maturation, podocyte-derived Ang-1 and mesangial-cell-derived Ang-2 may affect growth of nascent capillaries.