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Gene Information
Gene symbol: HSD11B1
Gene name: hydroxysteroid (11-beta) dehydrogenase 1
HGNC ID: 5208
Synonyms: SDR26C1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CASP8 | 1 hits |
| 2 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18218610 | Cortisol (an active GC) reduced the mRNA expression of caspase 8 (CASP8) and caspase 3 (CASP3) and reduced the enzymatic activity of CASP3 and cell death induced by tumor necrosis factor (TNF) and interferon gamma (IFNG) in cultured bovine luteal cells. mRNAs and proteins of GC receptor (NR3C1), 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1), and HSD11B2 were expressed in CL throughout the estrous cycle. |
| 2 | 18218610 | These results suggest that cortisol suppresses TNF-IFNG-induced apoptosis in vitro by reducing apoptosis signals via CASP8 and CASP3 in bovine CL and that the local increase in cortisol production resulting from increased HSD11B1 at the early and midluteal stages helps to maintain CL function by suppressing apoptosis of luteal cells. |