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Gene Information

Gene symbol: IL17A

Gene name: interleukin 17A

HGNC ID: 5981

Synonyms: IL-17A, IL-17

Related Genes

#	Gene Symbol	Number of hits
1	CSF2	1 hits
2	IFNG	1 hits
3	IL17RA	1 hits
4	IL23A	1 hits
5	STAT1	1 hits
6	TGFB1	1 hits

Related Sentences

#	PMID	Sentence
1	20038794	We used a mouse model of acute kidney ischemia-reperfusion injury (IRI) to test the hypothesis that early production of IL-23 and IL-12 following IRI activates downstream IL-17 and IFN-gamma signaling pathways and promotes kidney inflammation.
2	21321581	Activation of splenic T lymphocytes derived from protected mice in vitro with pharmacological agents that bypass the antigen receptor or immobilized anti-CD3 antibody resulted in enhanced expression of Ifng mRNA and protein without altering the expression of Il4, Il17, Il18, Inos and Tnfa genes nor the secretion of IL-2, IL-4, IL-17 and TNF-? proteins.
3	20471290	We identified epigenetic modifications across the clustered Il17a and Il17f and the Ifng loci before and after differential IL-12 or TGF-beta cytokine signaling, which induce divergent fates of Th17 cell precursors.
4	21516112	Autoreactive helper T cells specifically lacking GM-CSF failed to initiate neuroinflammation despite expression of IL-17A or IFN-?, whereas GM-CSF secretion by Ifng(-/-)Il17a(-/-) helper T cells was sufficient to induce experimental autoimmune encephalomyelitis (EAE).
5	21659501	It is noteworthy that we show that IL-17 mediates significant and reproducible enhancement of IL-1?/interferon (IFN)-?-induced and tumor necrosis factor (TNF)-?/IFN-?-induced apoptosis in human islets, rat ?-cells, and INS-1E cells, in association with significant upregulation of ?-cell IL17RA expression via activation of the transcription factors STAT1 and nuclear factor (NF)-?B.