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Gene Information
Gene symbol: STAT1
Gene name: signal transducer and activator of transcription 1, 91kDa
HGNC ID: 11362
Synonyms: STAT91, ISGF-3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IFNG | 1 hits |
| 2 | IL17A | 1 hits |
| 3 | IL17RA | 1 hits |
| 4 | IL26 | 1 hits |
| 5 | TBX21 | 1 hits |
| 6 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16934001 | The previously reported L706S, like the novel Q463H and E320Q alleles, are intrinsically deleterious for both interferon gamma (IFNG)-induced gamma-activating factor-mediated immunity and interferon alpha (IFNA)-induced interferon-stimulated genes factor 3-mediated immunity, as shown in STAT1-deficient cells transfected with the corresponding alleles. |
| 2 | 19848299 | By Day 15 of pregnancy, IFNs upregulate a large array of IFN responsive genes in the underlying stroma and glandular epithelium including ISG15, IRF1, STAT1, SLAs and B2M that likely have roles in uterine remodeling to support placentation. |
| 3 | 20947410 | Signaling through IL-26 receptor complexes results in the activation of STAT1 and STAT3 with subsequent induction of IL-26-responsive genes. |
| 4 | 16728393 | Therefore, we concluded that simultaneous activation of the STAT pathway by IFNG and of the ERK pathway by exogenous trophic factors played a role in the stage-specific IFNG-induced cytotoxicity in oligodendroglial progenitors. |
| 5 | 21659501 | It is noteworthy that we show that IL-17 mediates significant and reproducible enhancement of IL-1?/interferon (IFN)-?-induced and tumor necrosis factor (TNF)-?/IFN-?-induced apoptosis in human islets, rat ?-cells, and INS-1E cells, in association with significant upregulation of ?-cell IL17RA expression via activation of the transcription factors STAT1 and nuclear factor (NF)-?B. |
| 6 | 21646723 | Activation of the IFN-?/Stat1 signal pathway suppressed PMA-induced Mmp9 and Vegf gene expression in peritoneal macrophages. |
| 7 | 18549798 | This defect is not due to reduced activation of STAT1 or STAT4 or to impaired upregulation of the transcription factor T-bet. |