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Gene Information
Gene symbol: AFP
Gene name: alpha-fetoprotein
HGNC ID: 317
Synonyms: FETA
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD8A | 1 hits |
| 2 | HLA-A | 1 hits |
| 3 | HSPA1A | 1 hits |
| 4 | ICAM1 | 1 hits |
| 5 | IL18 | 1 hits |
| 6 | PLCG1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15457574 | Sequential immunization with a recombinant DNA vaccine encoding AFP and heat shock protein70 could generate effective AFP-specific T cell responses and induce definite antitumor effects on AFP-producing tumors, which may be suitable for some clinical testing as a vaccine for HCC. |
| 2 | 17462500 | Most importantly, The cytotoxic activity of CTLs against HepG2 with DC expressing AFP(AFP-DC) was significantly augmented by co-transduction with the IL-18 gene. |
| 3 | 17522860 | CD8 phenotypic and cytokine responses did not correlate with level of patient serum AFP antigen (between 74 and 463,040 ng/ml). |
| 4 | 18788625 | A transgenic DC vaccine was successfully constructed and the mAFP transgenic DCs expressed high level molecules of major MHC class I and II , B7.1, B7.2, CD18a, and CD54. |
| 5 | 18788625 | There was a significant difference between group B and other groups (P < 0.05). mAFP transgenic DC tumor vaccine inoculation may induce strong immunoprotection against liver carcinogenesis and tumor development and reduce PLC incidence induced by DEN/CCl4/ethanol. |
| 6 | 21491085 | In this study, we created a lentivirus expressing the AFP antigen and investigated the anti-tumor activity of AFP-specific CD8+ T cells, with and without CD4+ T cells, which were activated by either AFP peptide-pulsed or Lenti-AFP-engineered Dendritic cells (DCs) in vitro and in vivo. |