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Gene Information
Gene symbol: AKT1
Gene name: v-akt murine thymoma viral oncogene homolog 1
HGNC ID: 391
Synonyms: RAC, PKB, PRKBA, AKT
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CAT | 1 hits |
| 2 | CD8A | 1 hits |
| 3 | CDKN1B | 1 hits |
| 4 | IL2RA | 1 hits |
| 5 | ITGAM | 1 hits |
| 6 | MAPK3 | 1 hits |
| 7 | RAC1 | 1 hits |
| 8 | TLR2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11907644 | This surface contact mediated signal essentially interferes with the propagation of the interleukin 2 receptor signal by blocking the activation of the protein kinase B, also called Akt kinase, both in vitro and after experimental infection. |
| 2 | 16641451 | Herein, we show that SAG induces extracellular signal-regulated kinase 1 (ERK-1) and ERK-2 phosphorylation through phosphoinositide 3-kinase (PI3K), protein kinase C, and Ras activation and p38 mitogen-activated protein kinase (MAPK) phosphorylation through PI3K and Akt activation. |
| 3 | 19107122 | Retroviral transfer of a constitutively active form of Akt into the parental tumor significantly increased its resistance against E7-specific CD8(+) T-cell mediated apoptosis. |
| 4 | 19129452 | Evidence presented here shows that E4orf1 may also induce the phosphorylation of Akt and p70 S6K in a manner that depends on Rac1 and its guanine nucleotide exchange factor Tiam1. |
| 5 | 19864611 | Mac-1 conformational activation induced by ligand occupancy or activating Ab binding, but not integrin clustering, triggered similar patterns of intracellular protein tyrosine phosphorylation, including Akt phosphorylation, and inhibited spontaneous neutrophil apoptosis, indicating that global conformational changes are critical for Mac-1-dependent outside-in signal transduction. |
| 6 | 20558723 | Mutation of catalase (katG) sensitized F. tularensis to H(2)O(2) and enhanced PTEN oxidation, Akt phosphorylation, NF-kappaB activation, and inflammatory cytokine production. |
| 7 | 20696947 | Inhibiting mTOR, Akt, or protein kinase C in T cells abolished the costimulatory effects of the TLR2 agonist. |
| 8 | 11434724 | In vitro tissue culture studies showed that finely ground clinoptilolite inhibits protein kinase B (c-Akt), induces expression of p21WAF1/CIP1 and p27KIP1 tumor suppressor proteins, and blocks cell growth in several cancer cell lines. |