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Gene Information
Gene symbol: APC
Gene name: adenomatous polyposis coli
HGNC ID: 583
Synonyms: DP2, DP3, DP2.5, PPP1R46
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL3 | 1 hits |
| 2 | CD28 | 1 hits |
| 3 | CD4 | 1 hits |
| 4 | CD40 | 1 hits |
| 5 | CD40LG | 1 hits |
| 6 | CD83 | 1 hits |
| 7 | CD86 | 1 hits |
| 8 | CD8A | 1 hits |
| 9 | HSPA1A | 1 hits |
| 10 | ICOSLG | 1 hits |
| 11 | IFNG | 1 hits |
| 12 | MARK2 | 1 hits |
| 13 | MARVELD2 | 1 hits |
| 14 | PLP1 | 1 hits |
| 15 | PROCR | 1 hits |
| 16 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9550372 | Interaction of CD40 with its ligand (CD154) can induce CD40-bearing APCs to express immune stimulatory accessory molecules that facilitate immune recognition. |
| 2 | 11251876 | Firstly, mCT enhanced the B7-2 expression of APCs. |
| 3 | 15470057 | Bacterial HSPs enhanced MHC-II presentation only if peptide was complexed to the HSP, suggesting that the key HSP function was enhanced delivery or processing of chaperoned peptide Ag rather than generalized enhancement of APC function. |
| 4 | 16178769 | In particular, modulation of the expression of co-stimulatory molecules on the targeted APC; CD80, CD86, CD83 and B7RP-1, play important roles for the effect of the ADP-ribosylating CTA1-based adjuvants for the development of tolerance or active IgA immunity. |
| 5 | 17540847 | Here we compare monomeric and dimeric forms of MIP-1alpha and RANTES that target Id to APCs in a mouse B lymphoma (A20) and a multiple myeloma model (MOPC315). |
| 6 | 17540847 | When delivered in vivo by intramuscular injection of plasmids followed by electroporation, dimeric proteins efficiently primed APCs in draining lymph nodes for activation and proliferation of Id-specific CD4(+) T cells. |
| 7 | 19017952 | During T cell interaction with APC, CD28 is recruited to the central region (cSMAC) of the immunological synapse. |
| 8 | 19404546 | These biological functions of APC are associated with the endothelial protein C receptor (EPCR) and protease-activated receptor 1 (PAR-1) signalling pathways, which link the coagulation-inflammation responses. |
| 9 | 20346983 | CTLs cultured with STAT3-deficient APCs demonstrated a stronger proliferative response and produced increased amounts of IFN-gamma and TNF-alpha, all of which have been shown to be diminished in tumor-tolerized CD8 T cells. |
| 10 | 21048107 | Mechanistic dissection of this phenomenon shows that TRiC binds APC, and TRiC-chaperoned peptides are processed within the APC and presented on their MHC class I. |
| 11 | 15100266 | APCs process mammalian heat shock protein (HSP):peptide complexes to present HSP-chaperoned peptides on class I MHC (MHC-I) molecules to CD8(+) T cells. |
| 12 | 11043379 | The onset of a successful immune response lies within the control of the CD4+ T helper cells which, after specific antigen recognition, can up-regulate CD40L and subsequently activate APC through CD40 signaling. |
| 13 | 10092787 | DNA immunization with the myelin minigene for PLP-altered expression of B7.1 (CD80), and B7.2 (CD86) on APCs in the spleen. |
| 14 | 17339467 | Listeria monocytogenes (Lm) targets the cytoplasm of APC and is a strong CD8 and CD4 Th1-promoting vaccine vehicle in adult mice. |