Ignet

Gene symbol: APCS

Gene name: amyloid P component, serum

HGNC ID: 584

Synonyms: SAP, PTX2, MGC88159

Related Genes

#	Gene Symbol	Number of hits
1	CAMP	1 hits

Related Sentences

#	PMID	Sentence
1	21278351	Using human promonocytic cell line THP-1-derived macrophages as a cell model, we found that cells incubated with a hSAP-DNA complex showed significant defects in innate immune activations, whereas mouse SAP had similar, albeit very weak, activities. hSAP also significantly inhibited the functions of two identified DNA sentinels, high-mobility group B protein 1 and antimicrobial peptide LL37, and redirected DNA update to FcRs leading to endocytosis and endosomal degradation.