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Gene Information
Gene symbol: BCL2L1
Gene name: BCL2-like 1
HGNC ID: 992
Synonyms: BCLX, BCL2L, Bcl-X, bcl-xL, bcl-xS, PPP1R52
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BAX | 1 hits |
| 2 | BCL2 | 1 hits |
| 3 | CASP3 | 1 hits |
| 4 | CD19 | 1 hits |
| 5 | CD8A | 1 hits |
| 6 | IL2 | 1 hits |
| 7 | STAT1 | 1 hits |
| 8 | STAT3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11941452 | Indeed, DC activation effectively inhibited DC apoptosis, which was predominantly accompanied by the upregulation of Bcl-X(L) and to a lesser extent Bcl-2, while Bax and FLICE inhibitory protein (FLIP) remained unchanged. |
| 2 | 15153784 | We have shown that DNA encoding the anti-apoptotic protein Bcl-xL enhances E7-specific CD8+ T-cell responses and DNA encoding pro-apoptotic protein caspase-3 suppresses E7-specific CD8+ T-cell responses when co-administered intradermally via gene gun with DNA encoding human papillomavirus type 16 (HPV-16) E7 linked to the sorting signal of the lysosome-associated membrane protein type 1 (LAMP-1). |
| 3 | 15153784 | We demonstrated that vaccination with pVITRO achieved similar results to a co-administration strategy: that Bcl-xL enhanced the E7-specific CTL response and caspase-3 suppressed the E7-specific CTL response. |
| 4 | 15153784 | Thus, intradermal vaccination with a pVITRO vector combining an anti-apoptotic strategy (Bcl-xL) and an intracellular targeting strategy (SEL) further enhances the E7-specific CD8+ T-cell response and guarantees co-expression of both encoded molecules in transfected cells. |
| 5 | 15755994 | Further enhancement was achieved with IL-2 through induction of the antiapoptosis protein Bcl-x(L). |
| 6 | 20957227 | Sorted human CD19+CD27+ B cells were retrovirally transduced with the human B cell lymphoma (BCL)-6 and BCL-XL genes, and subsequently cultured in the presence of CD40-ligand and IL-21. |
| 7 | 21257966 | We further revealed that IL-21 promoted CD8 T cell survival in a mechanism dependent on activation of the STAT1 and STAT3 pathways and subsequent upregulation of the prosurvival molecules Bcl-2 and Bcl-x(L). |
| 8 | 21389868 | In addition, the frequency and functional activity of adoptively transferred OT-I cells, particularly memory CD8(+) T cells, were augmented by coadministration of sPD-1 DNA, which was closely associated with increased T-cell proliferation and reduced T-cell apoptosis through upregulation of Bcl-xL expression during T-cell activation. |