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Gene Information
Gene symbol: BCL6
Gene name: B-cell CLL/lymphoma 6
HGNC ID: 1001
Synonyms: ZBTB27, LAZ3, BCL5, BCL6A
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | ICOS | 1 hits |
| 3 | IL21 | 1 hits |
| 4 | IL6 | 1 hits |
| 5 | PRDM1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21636296 | We demonstrate that inducible costimulator (ICOS) provides a critical early signal to induce the transcription factor Bcl6, and Bcl6 then induces CXCR5, the canonical feature of Tfh cells. |
| 2 | 21636296 | Strikingly, a bifurcation between Tfh and effector Th cells was measurable by the second cell division of CD4(+) T cells, at day 2 after an acute viral infection: IL2R?(int) cells expressed Bcl6 and CXCR5 (Tfh cell program), whereas IL2R?(hi) cells exhibited strong Blimp1 expression that repressed Bcl6 (effector Th cell program). |
| 3 | 21423809 | The combined absence of IL-6 and IL-21 resulted in reduced Tfh differentiation and reduced Bcl6 protein expression. |
| 4 | 21423809 | Studying CD4 T cells in vitro, we found that high IL-21 production was not associated with high Bcl6 or CXCR5 expression. |
| 5 | 21423809 | TCR stimulation of purified naïve CD4 T cells in the presence of IL-6 also did not result in Tfh differentiation, as determined by Bcl6 or CXCR5 protein expression. |