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Gene Information
Gene symbol: CASP1
Gene name: caspase 1, apoptosis-related cysteine peptidase
HGNC ID: 1499
Synonyms: ICE
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CASP2 | 1 hits |
| 2 | CD4 | 1 hits |
| 3 | IL18 | 1 hits |
| 4 | IL1B | 1 hits |
| 5 | IL23A | 1 hits |
| 6 | IL4 | 1 hits |
| 7 | IL5 | 1 hits |
| 8 | PGA | 1 hits |
| 9 | TICAM1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17485153 | Aluminum-containing adjuvants stimulated the release of IL-1beta and IL-18 from DCs via caspase-1 activation. |
| 2 | 17485153 | Inhibition of IL-1beta and IL-18 secretion by DCs via inhibition of caspase-1 also led to a marked decrease of IL-4 and IL-5 by CD4(+) T cells. |
| 3 | 19737897 | Enhanced processing of IL-1beta directly correlated with increased activation of its upstream regulator, caspase-1, also known as IL-1beta-converting enzyme (ICE). |
| 4 | 19737897 | These results demonstrate that B. anthracis PGA elicits IL-1beta production through activation of ICE in PMA-differentiated THP-1 cells and hMoDCs, suggesting the potential for PGA as a therapeutic target for anthrax. |
| 5 | 18566365 | We have recently shown that alum activates caspase-1 and induces secretion of mature IL-1beta and IL-18. |
| 6 | 21490151 | LT enhanced IL-23 and IL-1? production from DCs via activation of ERK MAPK and IL-1? secretion through activation of caspase-1 and the NLRP3 inflammasome. |
| 7 | 21540455 | We show that the TRIF-biased signaling that is characteristic of low-toxicity MLA explains its failure to activate caspase-1. |
| 8 | 11007365 | The molecular machinery at the nexus of apoptosis and inflammation includes caspase-1 --an activator of IL-1beta and IL-18 - as well as the double-stranded-RNA-dependent protein kinase pathway and RNaseL pathway, which are key effectors of antiviral immunity. |
| 9 | 21464087 | VTRS1-induced macrophage cell death was significantly inhibited by a caspase-2 inhibitor but not a caspase-1 inhibitor. |