- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: CASP3
Gene name: caspase 3, apoptosis-related cysteine peptidase
HGNC ID: 1504
Synonyms: CPP32, CPP32B, Yama, apopain
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BCL2L1 | 1 hits |
| 2 | CASP8 | 1 hits |
| 3 | CD38 | 1 hits |
| 4 | CD8A | 1 hits |
| 5 | ERVWE1 | 1 hits |
| 6 | IFNG | 1 hits |
| 7 | IL6 | 1 hits |
| 8 | PARP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15153784 | We have shown that DNA encoding the anti-apoptotic protein Bcl-xL enhances E7-specific CD8+ T-cell responses and DNA encoding pro-apoptotic protein caspase-3 suppresses E7-specific CD8+ T-cell responses when co-administered intradermally via gene gun with DNA encoding human papillomavirus type 16 (HPV-16) E7 linked to the sorting signal of the lysosome-associated membrane protein type 1 (LAMP-1). |
| 2 | 15153784 | We demonstrated that vaccination with pVITRO achieved similar results to a co-administration strategy: that Bcl-xL enhanced the E7-specific CTL response and caspase-3 suppressed the E7-specific CTL response. |
| 3 | 15869795 | In addition, poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h. |
| 4 | 16907958 | These results suggest that CDV-Ond induced apoptosis by activating caspase-3, possibly through caspase-8 signaling rather than through p53/Bax-mediated, mitochondrial signaling in the infected cells. |
| 5 | 20930069 | In these cells, IL-6 prevented apoptosis by blocking caspase-3 and -7 activation through the induction of survivin. |
| 6 | 21505013 | Active and inactive SLE individuals had more CD38 molecules/CD8+ T cells and more CD4+ T, CD8+ T and B cells in apoptosis (as assessed by caspase-3 expression) than the control group. |
| 7 | 15585842 | Most importantly, evidence for T cell function, as measured by production of IFN-gamma, release of perforin, and activation of caspase-3 in target cells, was confined to Ag-expressing tumor. |
| 8 | 18242797 | The apoptotic pathway initiated by this interaction involves caspase-3-dependent mitochondrial depolarization and reactive oxygen species production, which depends on the phenotype of the envelope glycoprotein associated with the virus. |