About

Home

Introduction

Statistics

Programs

Dignet

Gene

GenePair

Help & Docs

Documents

Help

FAQs

Links

Acknowledge

Disclaimer

Contact Us

Gene Information

Gene symbol: CASP8

Gene name: caspase 8, apoptosis-related cysteine peptidase

HGNC ID: 1509

Synonyms: MCH5, MACH, FLICE, Casp-8

Related Genes

#	Gene Symbol	Number of hits
1	BCAR3	1 hits
2	CASP3	1 hits
3	FAS	1 hits
4	IL5	1 hits
5	RIPK1	1 hits
6	VTN	1 hits

Related Sentences

#	PMID	Sentence
1	7830531	Virtually all clinical isolates of group A streptococci secrete a highly conserved extracellular cysteine protease that cleaves human fibronectin and vitronectin, and converts IL-1 beta precursor to biologically active IL-1 beta.
2	16907958	These results suggest that CDV-Ond induced apoptosis by activating caspase-3, possibly through caspase-8 signaling rather than through p53/Bax-mediated, mitochondrial signaling in the infected cells.
3	20504922	Porcine reproductive and respiratory syndrome (PRRS) virus nonstructural protein 2 (nsp2) contains a cysteine protease domain at its N terminus, which belongs to the ovarian tumor (OTU) protease family.
4	20631334	Both subject groups showed strong proliferative responses (peripheral blood mononuclear cells) to the scabies antigens, but the crusted scabies group showed increased secretion of the Th2 cytokines interleukin 5 (IL-5) and IL-13 and decreased Th1 cytokine gamma interferon (IFN-gamma) in response to the active cysteine protease.
5	21368762	Casp8 suppresses RIP3-RIP1 (also known as RIPK3-RIPK1) kinase complex-dependent necroptosis that follows death receptor activation as well as a RIP3-dependent, RIP1-independent necrotic pathway that has emerged as a host defence mechanism against murine cytomegalovirus.
6	22009866	We suggest that the Lederle vaccine induces apoptosis by Fas receptor signaling, possibly through caspase-8 signaling rather than through mitochondrial signaling in the infected cells.