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Gene Information
Gene symbol: CCRN4L
Gene name: CCR4 carbon catabolite repression 4-like (S. cerevisiae)
HGNC ID: 14254
Synonyms: CCR4L, CCR4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCL22 | 1 hits |
| 2 | CD44 | 1 hits |
| 3 | CD8A | 1 hits |
| 4 | JAG1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21908423 | CCR4 antagonists, an emergent class of Treg inhibitor, have been shown to block recruitment of Tregs mediated by CCL22 and CCL17. |
| 2 | 21908423 | Immunization of transgenic or normal mice expressing tumor-associated self Ags (Her2/neu, OVA, gp100) with a CCR4 antagonist combined with various vaccines led to the induction of effector CD8(+) T cells and partial inhibition of tumor growth expressing self Ags in both prophylactic and therapeutic settings. |
| 3 | 21908423 | The CCR4 antagonist was more efficient than cyclophosphamide to elicit anti-self CD8(+) T cells. |
| 4 | 21908423 | We also showed that the population of Tregs expressing CCR4 corresponded to memory (CD44(high)) and activated (ICOS(+)) Tregs, an important population to be targeted to modulate Treg activity. |
| 5 | 21908423 | CCR4 antagonist represents a competitive class of Treg inhibitor able to induce functional anti-self CD8(+) T cells and tumor growth inhibition when combined with vaccines. |