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Gene Information

Gene symbol: CD44

Gene name: CD44 molecule (Indian blood group)

HGNC ID: 1681

Synonyms: IN, MC56, Pgp1, CD44R, HCELL, CSPG8

Related Genes

#	Gene Symbol	Number of hits
1	CCRN4L	1 hits
2	CD14	1 hits
3	CD34	1 hits
4	CD4	1 hits
5	CD80	1 hits
6	CD86	1 hits
7	CD8A	1 hits
8	IFNG	1 hits
9	IL15	1 hits
10	IL2	1 hits
11	IL4	1 hits
12	SELL	1 hits

Related Sentences

#	PMID	Sentence
1	8105441	All seven clones/lines were CD4+, CD8- and expressed high levels of CD44 and CD45RB surface markers.
2	7489749	Flow cytometric analysis of the cells during a 2-week culture revealed a loss of CD14 and CD34 expression, a concomittent increase of CD1a, CD11a,b and c, CD44, CD45, CD54, HLA-class I and II, and intermediate levels of CD26, CD80 and CD86.
3	10602007	While CD4(+) T cells under went a transient activation following immunization with gamma spz, CD8(+) T cells expanded robustly after spz challenge and exhibited stable expression of CD44(hi) and CD45RB(lo) during protracted protection.
4	11907108	By contrast, the mean fluorescence intensity of staining for the CD44 glycoprotein was diminished on CD8(+)D(b)p56(+) T cells from the I-A(b-/-) group, the level of CTL activity was lower on a per cell basis, and the relative prevalence of IFN-gamma(+)TNF-alpha(+) T cells detected after in vitro stimulation with the p56 peptide was decreased.
5	16313358	We found changes in cell-surface expression of CD11a, CD44, CD45RB, CD49d, CD54 and CD62L on Env-specific CD8(+) T cells that appeared to differentiate them from other CD8(+) T cells within 1 week to 1 month following immunization.
6	16275163	Direct injection of the OVA-, Ii-OVA-, or TfR-OVA-expressing vectors into mice resulted in a CD4(+) T cell response, as shown by expansion of adoptively transferred OT-II T cells and upregulation of CD44 on these cells.
7	17429840	When stimulated with antigen, they decreased CD62L, increased CD44 and CD25, and had no change in CD45RO expression.
8	19435919	Although both vectors induced a similar OVA-specific CD8(+) T-cell response in the long term, LM-OVA induced mainly central-phenotype (T(CM), CD44(high)CD62L(high)), whereas ST-OVA induced mainly effector-phenotype (T(EM), CD44(high)CD62L(low)) cells.
9	19712478	Splenocytes from mice infected with nonlethal MARV were harvested and stimulated with multiple overlapping 15-mer peptide pools, and reactive CD8+ T cells were evaluated for antigen specificity by measuring upregulation of CD44 and interferon-gamma expression.
10	20472099	In support, significant upregulation of CD44 on the surface of lymphocytes from DCNLGPCEA immunized mice was noticed with a substantial reduction in L-selectin (CD62L).
11	20635971	Moreover, treatment of tuberculous mice with Ag85AB-CpG-DDA induced higher production of type-I cytokines, generated more CD44-positive T cells and suppresses secretion of IL-4 as compared with untreated animals.
12	20086176	Interleukin-15 (IL-15) stimulates the diffrentiation and proliferation of T, B, and natural killer cells; enhances CD8(+) cytolytic T-ceII activity; helps maintain CD44(hi)CD8(+) memory T cells; and stimulates immunoglobulin synthesis by B cells.
13	19347042	In the P. berghei gamma-spz model, protection is linked to liver CD8+ T cells that express an effector/memory (T(EM)) phenotype, (CD44(hi)CD45RB(lo)CD62L(lo)), and produce IFN-gamma.
14	21720558	These CD4+CD44(hi)CD62L(lo)CD27? T cells concomitantly produce IFN-? and TNF-?, or IFN-?, IL-2 and TNF-? and have a higher cytokine median fluorescence intensity MFI or 'quality of response' than single cytokine producing cells.
15	21908423	We also showed that the population of Tregs expressing CCR4 corresponded to memory (CD44(high)) and activated (ICOS(+)) Tregs, an important population to be targeted to modulate Treg activity.