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Gene Information
Gene symbol: CIITA
Gene name: class II, major histocompatibility complex, transactivator
HGNC ID: 7067
Synonyms: C2TA, NLRA
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CALR | 1 hits |
| 2 | CD4 | 1 hits |
| 3 | CSF2 | 1 hits |
| 4 | HLA-A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12928384 | Expression of class II transactivator (CIITA) types I and III, but not IV, transcripts increases in response to GM-CSF. |
| 2 | 12928384 | Furthermore, GM-CSF increases the amount of CIITA associated with the DR promoter. |
| 3 | 16424052 | To determine if Ii expression affects presentation of MHC class II-restricted endogenously synthesized tumor antigens in human tumor cells, HLA-DR-MCF10 breast cancer cells were transduced with the CIITA, CD80 costimulatory molecule gene, and with or without small interfering RNAs (siRNA) specific for Ii. |
| 4 | 16424052 | Therefore, tumor cells transduced with the CIITA, CD80, and with or without Ii siRNA present endogenously synthesized tumor antigens and are potential vaccines for activating tumor-specific CD4+ T cells. |
| 5 | 18453624 | Furthermore, our data suggested that coadministration of DNA-encoding calreticulin (CRT) linked to human papillomavirus (HPV) 16 E6 Ag (CRT/E6) with CIITA DNA leads to enhanced E6-specific CD8(+) T cell immune responses in vaccinated mice. |