Ignet

Gene Information

Gene symbol: CXCL10

Gene name: chemokine (C-X-C motif) ligand 10

HGNC ID: 10637

Synonyms: IFI10, IP-10, crg-2, mob-1, C7, gIP-10

Related Genes

#	Gene Symbol	Number of hits
1	CAMP	1 hits
2	CCL17	1 hits
3	CCL2	1 hits
4	CCL22	1 hits
5	CCL3	1 hits
6	CD14	1 hits
7	CXCR3	1 hits
8	FOLR1	1 hits
9	IFIH1	1 hits
10	IFN1	1 hits
11	IFNAR1	1 hits
12	IFNG	1 hits
13	IL10	1 hits
14	IL12A	1 hits
15	IRF3	1 hits
16	TLR3	1 hits
17	TLR4	1 hits
18	TNF	1 hits
19	TNFSF10	1 hits

Related Sentences

#	PMID	Sentence
1	10632363	Furthermore, FBP peptides induced E39-specific CTLs and E39- and E41-specific IFN-gamma and IP-10 secretion in certain healthy donors.
2	11927652	Moreover, IFN-gamma-treated DC up-regulated the release of CXCL10 (IP-10) markedly and reduced the secretion of CCL17 TARC significantly, attracting preferentially T-helper (Th)1 and Th2 cells, respectively.
3	16499575	Also, IFN-alpha maturation leads to an increase in IP-10 and MCP-1 chemokine secretion, but only a minor increase in IL-12p40 secretion.
4	20068181	We took advantage of two TLR3-expressing tumor models that produced large amounts of CCL5 (a CCR5 ligand) and CXCL10 (a CXCR3 ligand) in response to type I IFN and poly(A:U), both in vitro and in vivo.
5	20549206	Both IFN-alphaR(-/-) and IFN-gamma(-/-) hosts failed to up-regulate the CXCL10 mRNA and recruit Tc1 cells to the tumor site, indicating non-redundant roles of type-1 and type-2 IFNs in the effects of poly-ICLC-assisted vaccines.
6	18957084	Antibody (Ab)-mediated inhibition of the most abundant serum CXCR3 ligand, CXCL10, in mice decreased the local production of CXCR3 ligands as well as Th1 cytokines expressed by local leukocytes, and lowered corresponding serum levels to reduce the severity of CYP-induced cystitis.
7	20427628	IP-10 production was also found to be a useful marker of M. leprae peptide responses, but its production was enhanced by IL-12 nonspecifically.
8	21049021	LL-37 also inhibited the ability of meningococcal CPS to induce nitric oxide release, as well as TNF? and CXCL10 (IP-10) release from TLR4-sufficient and TLR4-deficient murine macrophages.
9	20214479	Primary vaccine recipients had maximal levels of granulocyte-colony-stimulating factor on days 6-7 after vaccination; peak levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptor 1, interferon (IFN)-gamma, IFN-inducible protein-10 (IP-10), interleukin (IL)-6, and tissue inhibitor of metalloproteinases-1 on days 8-9 after vaccination; peak levels of soluble TNF receptor 2 and monokine induced by IFN-gamma (MIG) on days 10-11 after vaccination; and peak levels of granulocyte-macrophage-colony-stimulating factor on days 12-13 after vaccination.
10	20810726	Syncytia were also evident, along with significant basolateral secretion of proinflammatory chemokines, including IP-10, RANTES, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), interleukin 6 (IL-6), and IL-8.
11	21411535	Type I IFNs were partially responsible for the induction of CXCL10 on bystander DCs.
12	21497908	This process is involved in binding of IRF3 to the ISRE binding site in CXCL-10 promoter region.
13	21250864	Furthermore, expression of chemokine (C-X-C motif) ligand (CXCL10), tumor necrosis factor (TNF)-?, interleukin (IL)-6 and IL-12p70 was enhanced but IL-1? and IL-10 were stable or even downregulated.
14	21586124	The molecular signature observed ex vivo largely matched the one detected in CD14+ monocytes exposed in vitro to IFN?, including the induction of CXCL10 at the transcriptional and protein level.
15	17223980	MCP-1 and MIP-1alpha emerged at 4-5 h post-BCG exposure (early chemokines); IP-10 elevated at day 1 and peaked at day 2 (intermediate chemokine); and MDC elevated at day 1 and peaked at day 7 (late chemokine).
16	21728171	Monocytes and monocyte-derived DCs (MoDCs) engulfed MDA-5-activated cancer cells, and subsequently upregulated HLA-class I/II and costimulatory molecules, and secreted CXCL10 and IFN-?.