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Gene Information
Gene symbol: DPP4
Gene name: dipeptidyl-peptidase 4
HGNC ID: 3009
Synonyms: DPPIV
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CAV1 | 1 hits |
| 2 | CD14 | 1 hits |
| 3 | CD1A | 1 hits |
| 4 | CD28 | 1 hits |
| 5 | CD4 | 1 hits |
| 6 | CD86 | 1 hits |
| 7 | CD8A | 1 hits |
| 8 | IFNG | 1 hits |
| 9 | IL17D | 1 hits |
| 10 | IL2 | 1 hits |
| 11 | IL22 | 1 hits |
| 12 | NFKB1 | 1 hits |
| 13 | NPY | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1357035 | The expression of CD26 Ag, either in CD4+ or CD8+ cells, was clearly diminished in all the patients tested. |
| 2 | 7489749 | Flow cytometric analysis of the cells during a 2-week culture revealed a loss of CD14 and CD34 expression, a concomittent increase of CD1a, CD11a,b and c, CD44, CD45, CD54, HLA-class I and II, and intermediate levels of CD26, CD80 and CD86. |
| 3 | 15353589 | We now demonstrate that CD26 binds Caveolin-1 on antigen-presenting cells, and that residues 201-211 of CD26 along with the serine catalytic site at residue 630 contribute to binding to caveolin-1 scaffolding domain. |
| 4 | 15353589 | In addition, after CD26-caveolin-1 interaction on TT-loaded monocytes, caveolin-1 is phosphorylated, which links to activate NF-kappaB, followed by up-regulation of CD86. |
| 5 | 15353589 | Taken together, these results strongly suggest that CD26-caveolin-1 interaction plays a role in the up-regulation of CD86 on TT-loaded monocytes and subsequent engagement with CD28 on T cells, leading to antigen-specific T cell activation. |
| 6 | 18805447 | Neuropeptide Y (NPY)-induced modulation of the immune and inflammatory responses is regulated by tissue-specific expression of different receptor subtypes (Y1-Y6) and the activity of the enzyme dipeptidyl peptidase 4 (DP4, CD26) which terminates the action of NPY on Y1 receptor subtype. |
| 7 | 18657205 | Immunophenotypic analyses using multi-parameter flow cytometry and tetramer technology identified a unique pattern of CD26(high) expression among influenza-specific CD8(+) T cells, but not among CD8(+) T cells specific for CMV, EBV (three different epitopes) or HIV. |
| 8 | 18657205 | Furthermore, CD26(high) cells can produce interleukin-2. |
| 9 | 20702727 | Compared to CD26(-) DCs, the sheep CD26(+) DCs show 1) potent stimulation of allogeneic naive CD8(+) T cells with high selective induction of the Ifngamma and Il22 genes; 2) dominant efficacy in activating specific CD8(+) T cells against exogenous soluble Ag; and 3) selective expression of functional pathways associated with high capacity for Ag cross-presentation. |
| 10 | 21699939 | The differences between in vivo and in vitro effects of NPY on rat inflammatory cells functions are mostly due to dipeptidyl peptidase 4 activity. |